Hamasu K, Haraguchi T, Kabuki Y, Adachi N, Tomonaga S, Sato H, Denbow D M, Furuse M
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Amino Acids. 2009 Jul;37(2):377-82. doi: 10.1007/s00726-008-0164-0. Epub 2008 Aug 12.
The purpose of the present study was to clarify the central nervous system function of amino acids during acute stress. In Experiment 1, changes in free amino acid pattern were investigated in the brain of neonatal chicks exposed to either restraint with isolation-induced or fasting stress. L-proline and L-arginine were decreased in the telencephalon and diencephalon under any stress. Since the central nervous system functions of L-arginine during the stress response has recently been reported, in Experiment 2, the effect of intracerebroventricular injection of L-proline (0.5, 1.0, 2.0 micromol) during isolation-induced stress was investigated. L-proline induced sedative and hypnotic effects in a dose-dependent manner. It is suggested that L: -proline may have an important role to attenuate the stress response in the central nervous system of chicks.
本研究的目的是阐明急性应激期间氨基酸在中枢神经系统中的功能。在实验1中，研究了暴露于隔离诱导的束缚应激或禁食应激下的新生雏鸡大脑中游离氨基酸模式的变化。在任何应激情况下，端脑和间脑中的L-脯氨酸和L-精氨酸均减少。由于最近有报道称L-精氨酸在应激反应中的中枢神经系统功能，因此在实验2中，研究了在隔离诱导的应激期间脑室内注射L-脯氨酸（0.5、1.0、2.0微摩尔）的效果。L-脯氨酸以剂量依赖的方式诱导镇静和催眠作用。提示L-脯氨酸可能在减轻雏鸡中枢神经系统的应激反应中起重要作用。
