Central Research Institute for Feed and Livestock, ZEN-NOH (National Federation of Agricultural Co-operative Associations), Hokkaido, Japan.
Anim Sci J. 2009 Dec;80(6):624-30. doi: 10.1111/j.1740-0929.2009.00686.x.
An insertion/deletion variant of a thymine base (T5 and T6) in exon 2 of porcine beta 3-adrenergic receptor (ADRB3) gene has been described. In the current study, we made an association study between the ADRB3 polymorphisms and production traits in 735 Duroc pigs. The allele frequencies for the T5 and T6 alleles in our study population were 0.433 and 0.567, respectively. Any associations between ADRB3 genotype and average daily weight gain during test period, or backfat thickness and intramuscular fat content were not detected in either sex. However the size of the loin eye muscle area (EMA) was significantly associated with ADRB3 genotypes in gilts. T6-homozygous gilts had a higher mean of EMA (40.6 +/- 0.6 cm(2)) than T5-homozygous (38.1 +/- 0.4 cm(2), P = 0.002) and heterozygous (38.8 +/- 0.3 cm(2), P = 0.034) gilts. This association was not detected in males. In addition, a multiple traits animal model best linear unbiased predictor (BLUP) analysis revealed that the T6-homozygous genotype had positive effects on breeding value of EMA. Accordingly, we suggest that ADRB3 polymorphism has the potential to be an important genetic marker for prediction of EMA in Duroc pigs.
在猪的β3-肾上腺素能受体（ADRB3）基因外显子 2 中，胸腺嘧啶碱基（T5 和 T6）的插入/缺失变体已被描述。在目前的研究中，我们对 ADRB3 多态性与 735 头杜洛克猪的生产性状进行了关联研究。在我们的研究群体中，T5 和 T6 等位基因的等位基因频率分别为 0.433 和 0.567。在任何性别中，ADRB3 基因型与测试期间的平均日增重或背膘厚和肌内脂肪含量之间均未发现任何关联。然而，在小母猪中，腰眼肌肉面积（EMA）的大小与 ADRB3 基因型显著相关。T6 纯合小母猪的 EMA 平均值（40.6 +/- 0.6 cm(2)) 高于 T5 纯合子（38.1 +/- 0.4 cm(2)，P = 0.002)和杂合子（38.8 +/- 0.3 cm(2)，P = 0.034)小母猪。在雄性中未检测到这种关联。此外，多性状动物模型最佳线性无偏预测（BLUP）分析表明，T6 纯合基因型对 EMA 的育种值具有积极影响。因此，我们认为 ADRB3 多态性有可能成为预测杜洛克猪 EMA 的重要遗传标记。
