Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Finland.
Curr Opin Pharmacol. 2010 Apr;10(2):208-11. doi: 10.1016/j.coph.2010.01.004. Epub 2010 Feb 15.
Advances in clinical gene therapy have been modest although significant progress has been made during the past few years. New viruses have been introduced and new results have been collected from preclinical and clinical studies. This review will focus on cardiovascular and especially proangiogenic gene therapy. Recent results from preclinical developments and clinical trials will be discussed.
临床基因治疗的进展虽然缓慢,但过去几年已经取得了显著的进步。新的病毒已经被引入,并且从临床前和临床研究中收集了新的结果。本综述将重点关注心血管,特别是促血管生成基因治疗。将讨论最近的临床前发展和临床试验的结果。