Dickson Brendan C, Brooks John S, Pasha Theresa L, Zhang Paul J
Pennsylvania Hospital, Philadelphia, PA, USA.
Int J Surg Pathol. 2011 Feb;19(1):26-30. doi: 10.1177/1066896909352861. Epub 2010 Feb 16.
The DNA-binding factor TFE3 is closely related to microphthalmia-associated transcription factor (MiTF) and is over-expressed in alveolar soft part sarcoma (ASPS) and select renal cell carcinomas. Reports of TFE3 expression in PEComa prompted investigation into TFE3 expression among other members of the putative MiTF group of neoplasms. The authors examined cases of PEComa (n = 6), conventional angiomyolipoma (AML; n = 22), metastatic melanoma (n = 16), and clear cell sarcoma (CCS; n = 9) for TFE3 expression. Nuclear immunostaining was observed in 74% (39/53) of cases, as follows: 5/6 PEComas, 18/22 AMLs, 10/16 metastatic melanomas, and 6/9 CCSs. However, with the exception of PEComas, compared with ASPS controls, TFE3 staining was significantly less intense in the tumors examined. These results illustrate that TFE3 immunoreactivity is detectable in other members of the MiTF family of neoplasms. For this reason, such neoplasms warrant consideration in the differential diagnosis with nuclear TFE3 immunoreactivity, particularly when staining is focal and less intense.
DNA结合因子TFE3与小眼畸形相关转录因子（MiTF）密切相关，且在肺泡软组织肉瘤（ASPS）和某些肾细胞癌中过度表达。PEComa中TFE3表达的报告促使人们对假定的MiTF肿瘤组的其他成员中的TFE3表达进行研究。作者检测了PEComa病例（n = 6）、传统血管平滑肌脂肪瘤（AML；n = 22）、转移性黑色素瘤（n = 16）和透明细胞肉瘤（CCS；n = 9）中的TFE3表达情况。在74%（39/53）的病例中观察到核免疫染色，情况如下：5/6例PEComa、18/22例AML、10/16例转移性黑色素瘤和6/9例CCS。然而，除PEComa外，与ASPS对照相比，在所检测的肿瘤中TFE3染色强度明显较低。这些结果表明，在MiTF肿瘤家族的其他成员中可检测到TFE3免疫反应性。因此，在核TFE3免疫反应性的鉴别诊断中，这类肿瘤值得考虑，尤其是当染色为局灶性且强度较低时。
