调制 6MV 辐射场的生物学效应研究。
A study of the biological effects of modulated 6 MV radiation fields.
机构信息
Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK.
出版信息
Phys Med Biol. 2010 Mar 21;55(6):1607-18. doi: 10.1088/0031-9155/55/6/005. Epub 2010 Feb 17.
Abstract
The delivery of spatially modulated radiation fields has been shown to impact on in vitro cell survival responses. To study the effect of modulated fields on cell survival, dose response curves were determined for human DU-145 prostate, T98G glioma tumour cells and normal primary AGO-1552 fibroblast cells exposed to modulated and non-modulated field configurations delivered using a 6 MV Linac with multi-leaf collimator. When exposed to uniform fields delivered as a non-modulated or modulated configuration, no significant differences in survival were observed with the exception of DU-145 cells at a dose of 8 Gy (p = 0.024). Survival responses were determined for exposure to non-uniform-modulated beams in DU-145 and T98G and showed no deviation from the survival response observed following uniform non-modulated exposures. The results of these experiments indicate no major deviation in response to modulated fields compared to uniform exposures.
摘要
空间调制辐射场的传递已被证明会影响体外细胞存活反应。为了研究调制场对细胞存活的影响，我们测定了人前列腺 DU-145 细胞、T98G 神经胶质瘤肿瘤细胞和正常原代 AGO-1552 成纤维细胞在使用配备多叶准直器的 6 MV 直线加速器以调制和非调制场构型照射下的剂量反应曲线。当以非调制或调制构型照射时，除了 DU-145 细胞在 8 Gy 剂量下（p = 0.024）外，未观察到存活方面的显著差异。我们还测定了 DU-145 和 T98G 细胞在非均匀调制射束下的存活反应，与非均匀调制照射后的存活反应相比，没有明显的偏差。这些实验的结果表明，与均匀照射相比，对调制场的反应没有明显偏差。
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