Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, Israel.
Cornea. 2010 Apr;29(4):409-11. doi: 10.1097/ICO.0b013e3181bd9f8c.
To assess the possible damage to ocular tissues during treatment of keratoconus with UV-A-riboflavin corneal collagen cross-linking (CXL).
Single center, prospective, interventional study.
Fourteen eyes of 14 patients aged 28.2 ± 5.9 (mean ± SD) years with progressive keratoconus were treated with UV-A-riboflavin CXL. Corneal endothelium was assessed with the endothelial specular microscope. Central retina was assessed with biomicroscopy fundus examination and with optical coherence tomography using macular thickness protocol. Patients were assessed preoperatively, at week 1, month 1, 3, 6, 9, and 12 after treatment.
Comparative preoperative and postoperative results showed stable endothelial cell density (2730 cells/mm, 2793 cells/mm, and 2640 cells/mm, preoperatively, at month 6, and at month 12, respectively) and stable foveal thickness (203, 202, and 205 μm, preoperatively, at month 6, and at month 12, respectively). No morphological abnormalities were noted.
UV-A-riboflavin CXL seems to be a safe procedure that does not cause damage to the corneal endothelium and central retina.
评估在治疗圆锥角膜时使用紫外线-核黄素角膜胶原交联（CXL）治疗可能对眼组织造成的损害。
单中心、前瞻性、干预性研究。
对 14 名年龄 28.2±5.9（平均值±标准差）岁的进展性圆锥角膜患者的 14 只眼进行了紫外线-核黄素 CXL 治疗。使用内皮镜评估角膜内皮细胞。用生物显微镜眼底检查和黄斑厚度方案的光学相干断层扫描评估中央视网膜。在术前、术后第 1 周、第 1、3、6、9 和 12 个月进行评估。
与术前相比，术后比较结果显示内皮细胞密度稳定（分别为 2730 个/毫米、2793 个/毫米和 2640 个/毫米，术前、术后 6 个月和 12 个月），中心视网膜厚度稳定（分别为 203μm、202μm和 205μm，术前、术后 6 个月和 12 个月）。未观察到形态异常。
紫外线-核黄素 CXL 似乎是一种安全的程序，不会对角膜内皮细胞和中央视网膜造成损害。
