Headache Group-Department of Neurology, University of California, San Francisco, San Francisco, California 94115, USA.
Curr Opin Neurol. 2010 Jun;23(3):275-81. doi: 10.1097/WCO.0b013e3283378d5c.
Dopamine has been implicated in the pathophysiology of migraine, although its exact role remains unclear. Recent data offer some new perspective on a possible role for dopaminergic mechanisms in migraine. This review aims to summarize our current understanding of dopamine in migraine.
Direct application of dopamine and dopamine receptor agonists onto trigeminocervical complex neurons inhibits their activation after nociceptive stimulation. The dopaminergic A11 nucleus of the hypothalamus has been identified as the likely source of this dopamine. Recent evidence has shown that the genes for dopamine beta-hydroxylase and the dopamine transporter SLC6A3 may play a role in migraine pathophysiology, and dopamine has also been implicated in menstrual migraine.
Dopamine is currently considered to contribute to the pathophysiology of migraine, and dopamine receptor antagonists are prescribed in the treatment of acute migraine. Laboratory data suggest that the role of dopamine in migraine is more complex, perhaps due to the multiple receptors and levels of the brain involved in the disorder. These data suggest a reappraisal of dopaminergic therapeutic targets in migraine as our understanding of the role of this important biogenic amine is better characterized.
尽管多巴胺在偏头痛的病理生理学中的确切作用仍不清楚，但它已被认为与偏头痛的病理生理学有关。最近的数据为多巴胺能机制在偏头痛中的可能作用提供了一些新的视角。本综述旨在总结我们目前对偏头痛中多巴胺的理解。
直接将多巴胺和多巴胺受体激动剂应用于三叉颈复合体神经元，可抑制其在伤害性刺激后的激活。下丘脑的多巴胺 A11 核被认为是这种多巴胺的可能来源。最近的证据表明，多巴胺β-羟化酶和多巴胺转运体 SLC6A3 的基因可能在偏头痛的病理生理学中发挥作用，多巴胺也与月经性偏头痛有关。
多巴胺目前被认为有助于偏头痛的病理生理学，多巴胺受体拮抗剂被用于治疗急性偏头痛。实验室数据表明，多巴胺在偏头痛中的作用更为复杂，这可能是由于与该疾病相关的大脑中的多个受体和水平。这些数据表明，随着我们对这种重要生物胺作用的理解得到更好的描述，有必要重新评估偏头痛中的多巴胺能治疗靶点。
