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AML with CBFB-MYH11 rearrangement demonstrate RAS pathway alterations in 92% of all cases including a high frequency of NF1 deletions.

作者信息

Haferlach C, Dicker F, Kohlmann A, Schindela S, Weiss T, Kern W, Schnittger S, Haferlach T

出版信息

Leukemia. 2010 May;24(5):1065-9. doi: 10.1038/leu.2010.22. Epub 2010 Feb 18.

DOI:10.1038/leu.2010.22
PMID:20164853
Abstract
摘要

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AML with CBFB-MYH11 rearrangement demonstrate RAS pathway alterations in 92% of all cases including a high frequency of NF1 deletions.伴有CBFB-MYH11重排的急性髓系白血病在所有病例中有92%表现出RAS通路改变,包括高频率的NF1缺失。
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Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11.青少年粒单核细胞白血病的全基因组单核苷酸多态性分析表明,在与神经纤维瘤病相关的病例中,NF1基因座周围存在单亲二体性,而在具有RAS或PTPN11突变的病例中则不存在。
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