Welsford I G, Prior D J
Department of Biological Sciences, Northern Arizona University, Flagstaff 86011-5640.
J Exp Biol. 1991 Jan;155:1-19. doi: 10.1242/jeb.155.1.1.
Activation of the feeding motor program (FMP) increases the force of ventricular contractions in heart/central nervous system (CNS) preparations of the terrestrial slug Limax maximus (Linnaeus). The FMP-induced increase in ventricular activity requires innervation of the heart by abdominal ganglion nerves N9 and N11. Application of the small cardioactive peptides SCPA and SCPB to isolated preparations of the heart causes dose-dependent increases in the force of ventricular contractions. In addition, the SCPs induce rhythmic contractions in quiescent heart preparations. The effects of the SCPs appear to be specific in that the neuropeptide FMRFamide has an inhibitory effect on ventricular activity. SCP-like and FMRFamide-like immunoreactive material is found in the heart, kidney and pericardium and in the nerves that innervate these organs. Unilateral intracellular stimulation of buccal neuron B1, which contains SCP-like and FMRFamide-like immunoreactive material, mimics the FMP- and SCP-induced increases in ventricular activity. The effect of B1 on ventricular activity is frequency dependent and requires innervation of the heart by N11. These results are consistent with the hypothesis that the SCPs are involved in feeding-related alterations in heart activity in Limax and that the control of this effect involves neuron B1.
摄食运动程序（FMP）的激活会增加陆生蛞蝓大蛞蝓（林奈）心脏/中枢神经系统（CNS）制剂中心室收缩的力量。FMP诱导的心室活动增加需要腹神经节神经N9和N11对心脏进行神经支配。将小的心脏活性肽SCPA和SCPB应用于离体心脏制剂会导致心室收缩力量呈剂量依赖性增加。此外，SCPs会在静止的心脏制剂中诱导节律性收缩。SCPs的作用似乎具有特异性，因为神经肽FMRF酰胺对心室活动有抑制作用。在心脏、肾脏和心包以及支配这些器官的神经中发现了SCP样和FMRF酰胺样免疫反应性物质。对含有SCP样和FMRF酰胺样免疫反应性物质的颊神经元B1进行单侧细胞内刺激，可模拟FMP和SCP诱导的心室活动增加。B1对心室活动的影响取决于频率，并且需要N11对心脏进行神经支配。这些结果与以下假设一致：SCPs参与了大蛞蝓心脏活动中与摄食相关的变化，并且这种效应的控制涉及神经元B1。
