使用 2,3-不饱和-4-酮糖基供体的化学选择性糖基化反应。
Chemoselective glycosylations using 2,3-unsaturated-4-keto glycosyl donors.
机构信息
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
出版信息
Org Biomol Chem. 2010 Mar 7;8(5):988-90. doi: 10.1039/b925587g. Epub 2010 Jan 7.
DOI:10.1039/b925587g
PMID:20165785
Abstract
2,3-Unsaturated-4-keto glycosyl acetates were found to exhibit low reactivity under several glycosylation conditions. Chemoselective glycosylations were effectively performed using 2,3-unsaturated glycosyl and 2,3-dideoxy glycosyl acetates as armed glycosyl donors, and 2,3-unsaturated-4-keto glycosyl acetates as disarmed glycosyl donors.
摘要
2,3-不饱和-4-酮糖基乙酸酯在几种糖苷化条件下表现出低反应性。使用 2,3-不饱和糖基和 2,3-二脱氧糖基乙酸酯作为武装糖基供体，以及 2,3-不饱和-4-酮糖基乙酸酯作为非武装糖基供体，有效地进行了化学选择性糖苷化。
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