Department of Chemical Engineering, Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 May-Jun;2(3):249-59. doi: 10.1002/wnan.79.
Dendrimer conjugates for pharmaceutical development are capable of enhancing the local delivery of cytotoxic drugs. The ability to conjugate different targeting ligands to the dendrimer allows for the cytotoxic drug to be focused at the intended target cell while minimizing collateral damage in normal cells. Dendrimers offer several advantages over other polymer conjugates by creating a better defined, more monodisperse therapeutic scaffold. Toxicity from the dendrimer, targeted and nonspecific, is not only dependent upon the number of targeting and therapeutic ligands conjugated, but can be influenced by the repeating building blocks that grow the dendrimer, the dendrimer generation, as well as the surface termination.
用于药物开发的树枝状聚合物缀合物能够增强细胞毒性药物的局部递送。将不同的靶向配体缀合到树枝状聚合物上的能力可以使细胞毒性药物集中在预期的靶细胞上，同时最大限度地减少正常细胞的附带损伤。树枝状聚合物通过创建更明确、更单分散的治疗支架，提供了优于其他聚合物缀合物的几个优势。树枝状聚合物的毒性，无论是靶向的还是非特异性的，不仅取决于缀合的靶向和治疗配体的数量，还可以受到生长树枝状聚合物的重复构建块、树枝状聚合物的代数以及表面末端的影响。
