McDiarmid M A, Gurley H T, Arrington D
Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205.
J Occup Med. 1991 Feb;33(2):155-8.
The recognition of pharmaceuticals as biologically active chemical hazards is a recent occurrence. Focusing primarily on the hazard potential of antineoplastic drugs, many hospitals have adopted the safe handling guidelines proposed by the Occupational Safety and Health Administration (OSHA) to mitigate worker health risk. More recently, occupational health professionals are acknowledging that other drugs also are potentially hazardous to hospital workers and therefore require review. The approach used by one university hospital to identify other potentially hazardous drugs and to develop handling procedures for them involved assembling a multidisciplinary committee to perform drug reviews, prioritize agents for evaluation, define criteria for a "hazardous drug" determination, specify handling procedures for "hazardous drugs," and require detailed toxicologic data from hospital studies on investigational drugs.
将药品识别为具有生物活性的化学危害是最近才出现的情况。许多医院主要关注抗肿瘤药物的潜在危害，已采用职业安全与健康管理局（OSHA）提出的安全操作指南来降低工作人员的健康风险。最近，职业健康专业人员认识到其他药物对医院工作人员也有潜在危害，因此需要进行审查。一所大学医院用于识别其他潜在危险药物并为其制定处理程序的方法包括组建一个多学科委员会，以进行药物审查、确定评估药物的优先级、定义“危险药物”的判定标准、指定“危险药物”的处理程序，并要求提供医院对研究性药物研究的详细毒理学数据。
