Price Vision Group, 9002 N. Meridian Street, Indianapolis, IN 46260, USA.
J Refract Surg. 2010 Dec;26(12):972-9. doi: 10.3928/1081597X-20100212-08. Epub 2010 Feb 15.
To characterize central corneal thickness, curvature, and posterior surface elevation in eyes with Fuchs dystrophy that underwent Descemet membrane endothelial keratoplasty (DMEK) for endothelial decompensation and to compare these characteristics with those in normal eyes.
Pre- and postoperative corneal tomography was prospectively evaluated using Pentacam (Oculus Optikgeräte GmbH) imaging on 29 eyes with Fuchs dystrophy treated with DMEK. Results were compared with data from a separate cohort of 198 normal eyes.
In the Fuchs cohort, the mean preoperative central corneal thickness was 656 μm (range: 574 to 731 μm). This significantly exceeded the mean thickness of 542 μm in the normal cohort (range: 439 to 611 μm, P<.0001) although the cohort thickness ranges overlapped. One month after DMEK, mean central corneal thickness decreased significantly to 539 μm (range: 465 to 669 μm, P<.0001) with no further significant decrease between 1 and 3 months after DMEK (mean difference = -4 μm, P=.39). In the Fuchs cohort, keratometry (average Sim K and delta K) did not change significantly after DMEK (P=.41 and P=.44, respectively); pre- and postoperative values were comparable to those in the normal cohort. The mean forward displacement of the posterior surface increased by 69 μm 1 month after DMEK (P<.0001) without further significant change between 1 and 3 months.
After DMEK, central corneal thickness in the Fuchs dystrophy cohort decreased significantly and the posterior corneal surface displaced forward, without significant change in anterior keratometric values or keratometric astigmatism. The preoperative central corneal thickness range in eyes with confluent central guttata overlapped the range in normal corneas.
描述行 Descemet 膜内皮角膜移植术（DMEK）治疗内皮失代偿的 Fuchs 营养不良性角膜病变患者的中央角膜厚度、曲率和后表面抬高，并将这些特征与正常眼进行比较。
前瞻性地使用 Pentacam（Oculus Optikgeräte GmbH）对 29 只行 DMEK 治疗的 Fuchs 营养不良性角膜病变眼进行术前和术后角膜断层成像，并与单独的 198 只正常眼的队列数据进行比较。
在 Fuchs 组中，术前中央角膜厚度的平均值为 656μm（范围：574 至 731μm）。这明显超过了正常组的平均值 542μm（范围：439 至 611μm，P<.0001），尽管两组的厚度范围有重叠。DMEK 后 1 个月，中央角膜厚度显著下降至 539μm（范围：465 至 669μm，P<.0001），DMEK 后 1 至 3 个月间无进一步显著下降（平均差异=-4μm，P=.39）。在 Fuchs 组中，DMEK 后角膜曲率（平均 Sim K 和 delta K）无明显变化（分别为 P=.41 和 P=.44）；术前和术后值与正常组相似。DMEK 后 1 个月，后表面向前位移平均增加 69μm（P<.0001），1 至 3 个月间无进一步显著变化。
DMEK 后，Fuchs 营养不良性角膜病变组的中央角膜厚度显著下降，后角膜表面向前移位，前角膜曲率值或角膜散光无明显变化。合并中央大泡性病变的眼的术前中央角膜厚度范围与正常角膜重叠。
