Ye Longwu, Cui Li, Zhang Guozhu, Zhang Liming
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.
J Am Chem Soc. 2010 Mar 17;132(10):3258-9. doi: 10.1021/ja100041e.
An expedient and reliable method for accessing reactive alpha-oxo gold carbenes via gold-catalyzed intermolecular oxidation of terminal alkynes has been developed. Significantly, this method offers a safe and economical alternative to the strategies based on diazo substrates. Its synthetic potential is demonstrated by expedient preparation of dihydrofuran-3-ones containing a broad range of functional groups.
已开发出一种通过金催化的末端炔烃分子间氧化来制备活性α-氧代金卡宾的便捷可靠方法。值得注意的是,该方法为基于重氮底物的策略提供了一种安全且经济的替代方案。通过便捷地制备含有广泛官能团的二氢呋喃-3-酮,证明了其合成潜力。