Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, and Clinical Research Center, Oulu University Hospital, Oulu, Finland.
Ann Med. 2010 Mar;42(2):131-7. doi: 10.3109/07853890903449827.
A low adiponectin level is associated with high blood pressure which, in turn, often results in left ventricular hypertrophy. We evaluated the association between plasma adiponectin concentrations and echocardiographic measurements, including left ventricular mass index (LVMI), in 933 middle-aged subjects consisting of 453 hypertensives and 480 controls.
Plasma adiponectin concentrations were measured with an enzyme-linked immunosorbent assay (ELISA) method. One experienced cardiologist performed echocardiographic examinations, and LVMI was calculated according to Devereux's method.
Low plasma adiponectin levels were independently associated with increased intraventricular septum thickness, posterior ventricular wall thickness, and left ventricular mass index (P<0.001) in the whole cohort. In the subgroup analysis, the association between these echocardiographic parameters and adiponectin concentrations was observed only in the hypertensive cohort although fractional shortening revealed an association with adiponectin levels also in the control cohort (P=0.021). Findings remained significant after adjustment for the major risk factors for LVMI, such as age, sex, smoking, and systolic blood pressure.
This study in a large population sample detected an association between low plasma adiponectin concentration and LVMI, a marker of left ventricular hypertrophy. This association may be one of the factors that could explain the reported increased cardiovascular risk in subjects with low adiponectin levels.
低脂联素水平与高血压有关，而高血压往往会导致左心室肥厚。我们评估了 933 名中年受试者（包括 453 名高血压患者和 480 名对照者）的血浆脂联素浓度与超声心动图测量值（包括左心室质量指数[LVMI]）之间的关系。
采用酶联免疫吸附试验（ELISA）法测定血浆脂联素浓度。一位有经验的心脏病专家进行了超声心动图检查，并根据 Devereux 法计算 LVMI。
在整个队列中，低血浆脂联素水平与室间隔厚度、后壁厚度和左心室质量指数的增加独立相关（P<0.001）。在亚组分析中，尽管在对照组中，射血分数与脂联素水平也存在相关性（P=0.021），但这些超声心动图参数与脂联素浓度之间的相关性仅在高血压组中观察到。在调整了 LVMI 的主要危险因素（如年龄、性别、吸烟和收缩压）后，这些发现仍然具有统计学意义。
本研究在一个大型人群样本中发现，低血浆脂联素浓度与 LVMI（左心室肥厚的标志物）之间存在关联。这种关联可能是解释报告中的低脂联素水平患者心血管风险增加的因素之一。
