Dep. 828, Molecular Neurobiology, Ottiliavej 9, DK-2500 Valby, Denmark.
Curr Pharm Biotechnol. 2010 Feb;11(2):167-74. doi: 10.2174/138920110790909731.
Cell-penetrating peptides (CPP), also called protein transduction domains (PTD), membrane-permeable peptides (MPP), or Trojan horse peptides, have been used in many different research areas. The delivery of heat shock proteins (Hsp) using CPP has been applied in models for apoptosis, necrosis, oxidative stress, neurodegenerative diseases, stroke, cystic fibrosis, smooth muscle relaxation, myocardial injury, scar formation, and others. This review summarizes the accomplishments of the field over the last years and discusses why Hsp are particularly suitable for CPP-mediated delivery.
细胞穿透肽（CPP），也称为蛋白转导结构域（PTD）、膜透肽（MPP）或特洛伊木马肽，已被应用于许多不同的研究领域。使用 CPP 递呈热休克蛋白（Hsp）已被应用于细胞凋亡、细胞坏死、氧化应激、神经退行性疾病、中风、囊性纤维化、平滑肌松弛、心肌损伤、瘢痕形成等模型中。本综述总结了近年来该领域的成就，并讨论了为什么 Hsp 特别适合 CPP 介导的递呈。
