Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka, Street, 31-531 Cracow, Poland.
Curr Pharm Des. 2010;16(10):1214-23. doi: 10.2174/138161210790945940.
Orexigenic peptides are group of endocrine hormones exerting a pleiotropic influence on many physiological functions including regulation of the feeding behaviour and energy expenditure, release of growth hormone (GH) and inotropic effects on the heart. Some of these peptides such as ghrelin, originally identified in the gastric mucosa, has been involved not only in control of food intake and growth hormone release but also exerts the immunomodulatory and anti-inflammatory properties. This review summarizes the recent attempts to prove the concept that orexigenic peptides such as ghrelin, orexin-A and obestatin besides playing an important role in the mechanism of food intake, exhibit a potent gastroprotective action against the formation of acute gastric mucosal injury induced by various ulcerogens. This protective effect depends upon vagal activity and hyperemia mediated by NOS/NO and COX/PG systems and CGRP released from sensory afferent nerves. In addition, the appetite peptides such as ghrelin and orexin-A are implicated in the mechanism of the healing of preexisting gastric ulcers due to an activation of specific GHS-R1a and OX-R1 receptors and PG/COX system.
食欲肽是一组内分泌激素，对许多生理功能具有多效性影响，包括调节摄食行为和能量消耗、生长激素 (GH) 的释放以及对心脏的变力作用。这些肽中的一些，如最初在胃黏膜中发现的胃饥饿素，不仅参与了控制食物摄入和生长激素释放，而且还具有免疫调节和抗炎作用。本文综述了最近的一些尝试，以证明这样的概念，即食欲肽，如胃饥饿素、食欲素-A 和 obestatin，除了在进食机制中发挥重要作用外，还对各种溃疡原诱导的急性胃黏膜损伤具有强大的胃保护作用。这种保护作用取决于迷走神经活动和由 NOS/NO 和 COX/PG 系统以及感觉传入神经释放的 CGRP 介导的充血。此外，由于特定的 GHS-R1a 和 OX-R1 受体和 PG/COX 系统的激活，食欲肽（如胃饥饿素和食欲素-A）参与了现有胃溃疡愈合的机制。
