Department of Medical Microbiology, Leiden University Medical Centre, Leiden, The Netherlands.
Clin Microbiol Infect. 2011 Feb;17(2):312-5. doi: 10.1111/j.1469-0691.2010.03195.x.
A retrospective nationwide survey on the occurrence of Capnocytophaga canimorsus and Capnocytopaga cynodegmi infections in The Netherlands over 3 years showed 32 cases, of which 31 were caused by C. canimorsus and one by an unspecified oxidase-positive Capnocytophaga strain. Twenty-eight patients had been diagnosed by blood culture, one by culture from both blood and cerebrospinal fluid (CSF), one by culture from a conjunctival swab, and two patients by 16S rRNA gene amplification by PCR directly from a blood or CSF specimen. The incidence rate was 0.67 infections per million population. Bacteraemia was found in 94% of the cases. The age range of patients was 38-80 years; 72% of them were male. Among 26 patients from whom clinical data were available, splenectomy was not reported, but alcoholism was reported in five. Nine patients (35%) had been admitted to the intensive-care unit, and three patients (13%) died. The mortality rate was much lower than observed in previous studies.
一项对荷兰 3 年来卡他莫拉菌和嗜二氧化碳噬纤维菌感染的回顾性全国性调查显示，共发生 32 例感染，其中 31 例由卡他莫拉菌引起，1 例由未确定的氧化酶阳性卡他莫拉菌引起。28 例患者通过血培养确诊，1 例通过血液和脑脊液（CSF）的培养确诊，1 例通过结膜拭子培养确诊，2 例患者通过聚合酶链反应（PCR）直接从血液或 CSF 标本中 16S rRNA 基因扩增确诊。发病率为每百万人口 0.67 例感染。94%的病例存在菌血症。患者年龄范围为 38-80 岁，72%为男性。在 26 名可提供临床数据的患者中，未报告脾切除术，但有 5 名患者报告有酗酒史。9 名（35%）患者入住重症监护病房，3 名（13%）患者死亡。死亡率明显低于以往研究的观察结果。
