1-（羧基苄基）咪唑-5-丙烯酸：强效且选择性的血管紧张素II受体拮抗剂。 - Suppr

1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.

作者信息

Weinstock J, Keenan R M, Samanen J, Hempel J, Finkelstein J A, Franz R G, Gaitanopoulos D E, Girard G R, Gleason J G, Hill D T

机构信息

Research and Development Division, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.

出版信息

J Med Chem. 1991 Apr;34(4):1514-7. doi: 10.1021/jm00108a043.

DOI:10.1021/jm00108a043

PMID:2016730

Abstract

摘要

相似文献

1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.1-（羧基苄基）咪唑-5-丙烯酸：强效且选择性的血管紧张素II受体拮抗剂。

J Med Chem. 1991 Apr;34(4):1514-7. doi: 10.1021/jm00108a043.

Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids.

J Med Chem. 1993 Jun 25;36(13):1880-92. doi: 10.1021/jm00065a011.

Pharmacological profile of GR117289 in vitro: a novel, potent and specific non-peptide angiotensin AT1 receptor antagonist.GR117289的体外药理学特性：一种新型、强效且特异性的非肽类血管紧张素AT1受体拮抗剂。

Br J Pharmacol. 1992 Dec;107(4):1173-80. doi: 10.1111/j.1476-5381.1992.tb13425.x.

Diphenylpropionic acids as new AT1 selective angiotensin II antagonists.二苯基丙酸类作为新型AT1选择性血管紧张素II拮抗剂。

J Med Chem. 1996 May 24;39(11):2197-206. doi: 10.1021/jm9508853.

Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists.

J Med Chem. 1995 Sep 15;38(19):3759-71. doi: 10.1021/jm00019a005.

Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566.

J Pharmacol Exp Ther. 1992 Jan;260(1):175-81.

Different prejunctional and postjunctional responses to angiotensin II and AT1-receptor inhibition: influence of maturation.

J Cardiovasc Pharmacol. 2004 Mar;43(3):432-9. doi: 10.1097/00005344-200403000-00015.

Structure elucidation and conformational properties of eprosartan, a non peptide angiotensin II AT1 antagonist.

J Pharm Biomed Anal. 2002 Apr 1;28(1):125-35. doi: 10.1016/s0731-7085(01)00603-3.

Non-peptide angiotensin II receptor antagonists. II. Pharmacology of S-8308.非肽类血管紧张素II受体拮抗剂。II. S-8308的药理学

Eur J Pharmacol. 1988 Nov 15;157(1):13-21. doi: 10.1016/0014-2999(88)90465-7.

Nonpeptide angiotensin II receptor antagonists: insurmountable angiotensin II antagonism of EXP3892 is reversed by the surmountable antagonist DuP 753.非肽类血管紧张素II受体拮抗剂：EXP3892的不可逾越性血管紧张素II拮抗作用可被可逾越性拮抗剂DuP 753逆转。

J Pharmacol Exp Ther. 1991 Jul 1;258(1):49-57.

引用本文的文献

Exploiting Knowledge on Structure-Activity Relationships for Designing Peptidomimetics of Endogenous Peptides.利用结构-活性关系知识设计内源性肽的肽模拟物。

Biomedicines. 2021 Jun 7;9(6):651. doi: 10.3390/biomedicines9060651.

Rational Design and Synthesis of AT1R Antagonists.血管紧张素受体拮抗剂的合理设计与合成。

Molecules. 2021 May 14;26(10):2927. doi: 10.3390/molecules26102927.

Facile and efficient syntheses of a series of N-benzyl and N-biphenylmethyl substituted imidazole derivatives based on (E)-urocanic acid, as angiotensin II AT1 receptor blockers.基于（E）-尿刊酸，简便高效地合成了一系列 N-苄基和 N-联苯甲基取代的咪唑衍生物，作为血管紧张素 II AT1 受体阻断剂。

Molecules. 2013 Jun 27;18(7):7510-32. doi: 10.3390/molecules18077510.

Methyl 2,5-dichloro-benzoate.2,5-二氯苯甲酸甲酯。

Acta Crystallogr Sect E Struct Rep Online. 2008 Sep 20;64(Pt 10):o1970. doi: 10.1107/S1600536808029541.

Inhibition of angiotensin II-induced inositol phosphate production by triacid nonpeptide antagonists in CHO cells expressing human AT1 receptors.在表达人AT1受体的CHO细胞中，三酸非肽拮抗剂对血管紧张素II诱导的肌醇磷酸生成的抑制作用。

Pharm Res. 2000 Dec;17(12):1482-8. doi: 10.1023/a:1007600924033.

Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype.缬沙坦的药理学特性：一种强效、口服活性的血管紧张素II AT1受体亚型非肽拮抗剂。

Br J Pharmacol. 1993 Oct;110(2):761-71. doi: 10.1111/j.1476-5381.1993.tb13877.x.

Human AT1 receptor is a single copy gene: characterization in a stable cell line.

Mol Cell Biochem. 1994 Feb 9;131(1):75-86. doi: 10.1007/BF01075727.

Differentiation between binding sites for angiotensin II and nonpeptide antagonists on the angiotensin II type 1 receptors.血管紧张素II 1型受体上血管紧张素II结合位点与非肽拮抗剂结合位点的区分

Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7046-50. doi: 10.1073/pnas.91.15.7046.

A pharmacodynamic study of SR 47436, a selective AT1 receptor antagonist, on blood pressure in conscious cynomolgus monkeys.选择性AT1受体拮抗剂SR 47436对清醒食蟹猴血压的药效学研究。

Br J Pharmacol. 1994 Jan;111(1):145-50. doi: 10.1111/j.1476-5381.1994.tb14036.x.

Derivation of a 3D pharmacophore model for the angiotensin-II site one receptor.血管紧张素II 1型受体的三维药效团模型的推导

J Comput Aided Mol Des. 1994 Oct;8(5):491-512. doi: 10.1007/BF00123662.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献