表皮生长因子受体基因在肾细胞癌中的扩增。
Amplification of epidermal growth factor receptor gene in renal cell carcinoma.
机构信息
Oncology Business Unit, GlaxoSmithKline, London UB11 1BT, United Kingdom.
出版信息
Eur J Cancer. 2010 Mar;46(5):859-62. doi: 10.1016/j.ejca.2010.01.011. Epub 2010 Feb 16.
PMID:20167476
Abstract
Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.
摘要
表皮生长因子受体 (EGFR) 的表达可能对肾细胞癌 (RCC) 的预后具有价值。在之前报道的一项随机研究中，对 315 例晚期 RCC 患者的队列进行了 EGFR 基因扩增的研究。通过荧光原位杂交，只有 2 例患者（0.6%）存在基因扩增；因此，基因扩增对 RCC 无预后价值。
Zotero 插件