Epilepsy Center, Department of Neurological Sciences, Federico II University, Naples, Italy.
Seizure. 2010 Apr;19(3):198-201. doi: 10.1016/j.seizure.2010.01.009. Epub 2010 Feb 18.
We describe the ictal [(18)F]FDG-PET study of a case of absence status showing bilateral thalamic hypermetabolism and frontal cortex hypometabolism. This is the first ictal assessment of absence status by [(18)F]FDG-PET reporting this particular cortical and subcortical involvement. Our findings support the theory of corticothalamic circuitry involvement in the pathophysiology of absence seizures and stress the similarities of the clinical and metabolic pattern observed during absences with the pattern of task-induced interruption of the default state of brain function.
我们描述了一例失神发作持续状态的 [(18)F]FDG-PET 研究，表现为双侧丘脑代谢亢进和额叶皮质代谢低下。这是首例通过 [(18)F]FDG-PET 对失神发作持续状态进行的发作期评估，报告了这种特殊的皮质和皮质下受累。我们的发现支持了皮质-丘脑回路参与失神发作的病理生理学的理论，并强调了在失神发作期间观察到的临床和代谢模式与任务诱导中断大脑功能默认状态的模式之间的相似性。
