受体酪氨酸激酶跨膜结构域：功能、二聚体结构和二聚化能。
Receptor tyrosine kinase transmembrane domains: Function, dimer structure and dimerization energetics.
机构信息
Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA.
出版信息
Cell Adh Migr. 2010 Apr-Jun;4(2):249-54. doi: 10.4161/cam.4.2.10725. Epub 2010 Apr 23.
Abstract
The transmembrane (TM) domains of receptor tyrosine kinases (RTKs) play an active role in signaling. They contribute to the stability of full-length receptor dimers and to maintaining a signaling-competent dimeric receptor conformation. In an exciting new development, two structures of RTK TM domains have been solved, a break-through achievement in the field. Here we review these structures, and we discuss recent studies of RTK TM domain dimerization energetics, possible synergies between domains, and the effects of pathogenic RTK TM mutations on structure and dimerization.
摘要
受体酪氨酸激酶 (RTK) 的跨膜 (TM) 结构域在信号转导中发挥着积极作用。它们有助于全长受体二聚体的稳定性，并维持信号传导有效的二聚体受体构象。在一个令人兴奋的新发展中，两个 RTK TM 结构域的结构已经被解决，这是该领域的一个突破成就。在这里，我们回顾这些结构，并讨论 RTK TM 结构域二聚化能学的最新研究、不同结构域之间的协同作用，以及致病 RTK TM 突变对结构和二聚化的影响。
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