• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

免疫遗传学与人嗜T淋巴细胞病毒1型（HTLV-1）相关脊髓病/热带痉挛性截瘫（HAM/TSP）的病理机制

Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).

作者信息

Saito Mineki

机构信息

Department of Immunology, Graduate School of Medicine, University of the Ryukyus, Uehara 207, Nishihara-cho, Nakagami-gun, Okinawa 903-0215, Japan.

出版信息

Interdiscip Perspect Infect Dis. 2010;2010:478461. doi: 10.1155/2010/478461. Epub 2010 Feb 10.

DOI:10.1155/2010/478461
PMID:20169122
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2821641/
Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is a replication-competent human retrovirus associated with two distinct types of disease only in a minority of infected individuals: the malignancy known as adult T-cell leukemia (ATL) and a chronic inflammatory central nervous system disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although the factors that cause these different manifestations of HTLV-1 infection are not fully understood, accumulating evidence suggests that complex virus-host interactions play an important role in determining the risk of HAM/TSP. This review focuses on the role of the immune response in controlling or limiting viral persistence in HAM/TSP patients, and the reason why some HTLV-1-infected people develop HAM/TSP whereas the majority remains asymptomatic carriers of the virus.

摘要

人类嗜T细胞病毒1型（HTLV-1）是一种具有复制能力的人类逆转录病毒，仅在少数受感染个体中引发两种不同类型的疾病：一种被称为成人T细胞白血病（ATL）的恶性肿瘤，以及一种慢性炎症性中枢神经系统疾病——HTLV-1相关脊髓病/热带痉挛性截瘫（HAM/TSP）。尽管导致HTLV-1感染出现这些不同表现的因素尚未完全明确，但越来越多的证据表明，复杂的病毒-宿主相互作用在决定HAM/TSP风险方面起着重要作用。本综述聚焦于免疫反应在控制或限制HAM/TSP患者体内病毒持续存在中的作用，以及一些HTLV-1感染者会发展为HAM/TSP而大多数人仍为该病毒无症状携带者的原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647f/2821641/2a16f6e447cb/IPID2010-478461.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647f/2821641/2a16f6e447cb/IPID2010-478461.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647f/2821641/2a16f6e447cb/IPID2010-478461.001.jpg

相似文献

1
Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).免疫遗传学与人嗜T淋巴细胞病毒1型（HTLV-1）相关脊髓病/热带痉挛性截瘫（HAM/TSP）的病理机制
Interdiscip Perspect Infect Dis. 2010;2010:478461. doi: 10.1155/2010/478461. Epub 2010 Feb 10.
2
Immunopathogenesis of human T-cell leukemia virus type-1-associated myelopathy/tropical spastic paraparesis: recent perspectives.人类T细胞白血病病毒1型相关脊髓病/热带痉挛性截瘫的免疫发病机制：最新观点
Leuk Res Treatment. 2012;2012:259045. doi: 10.1155/2012/259045. Epub 2012 Feb 6.
3
The Impact of Immune Response on HTLV-I in HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).免疫应答对 HTLV-I 相关脊髓病/热带痉挛性截瘫（HAM/TSP）中 HTLV-I 的影响。
Iran J Basic Med Sci. 2013 Mar;16(3):235-41.
4
Current Perspectives in Human T-Cell Leukemia Virus Type 1 Infection and Its Associated Diseases.人类1型嗜T细胞白血病病毒感染及其相关疾病的当前观点
Front Med (Lausanne). 2022 Apr 8;9:867478. doi: 10.3389/fmed.2022.867478. eCollection 2022.
5
Mediators of central nervous system damage during the progression of human T-cell leukemia type I-associated myelopathy/tropical spastic paraparesis.I型人类T细胞白血病相关脊髓病/热带痉挛性截瘫进展过程中中枢神经系统损伤的介质
J Neurovirol. 2003 Oct;9(5):522-9. doi: 10.1080/13550280390218689.
6
Immunopathogenesis of HTLV-1-assoaciated myelopathy/tropical spastic paraparesis (HAM/TSP).人类嗜 T 淋巴细胞病毒 1 相关脊髓病/热带痉挛性截瘫（HAM/TSP）的免疫发病机制。
Life Sci. 2014 May 28;104(1-2):9-14. doi: 10.1016/j.lfs.2014.03.025. Epub 2014 Apr 3.
7
Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).人类嗜 T 细胞病毒 1 相关脑脊髓病/热带痉挛性截瘫（HAM/TSP）的免疫病毒学标志物。
Retrovirology. 2019 Nov 29;16(1):35. doi: 10.1186/s12977-019-0499-5.
8
Presence of tropical spastic paraparesis/human T-cell lymphotropic virus type 1-associated myelopathy (TSP/HAM)-like among HIV-1-infected patients.1型人类嗜T细胞病毒相关脊髓病/热带痉挛性截瘫（TSP/HAM）样病症在HIV-1感染患者中的存在情况。
J Med Virol. 2008 Mar;80(3):392-8. doi: 10.1002/jmv.21111.
9
Tropical spastic paraparesis and HTLV-1 associated myelopathy: clinical, epidemiological, virological and therapeutic aspects.热带痉挛性截瘫和 HTLV-1 相关脊髓病：临床、流行病学、病毒学和治疗方面。
Rev Neurol (Paris). 2012 Mar;168(3):257-69. doi: 10.1016/j.neurol.2011.12.006. Epub 2012 Mar 7.
10
T cell receptor repertoire analysis in HTLV-1-associated diseases.T 细胞受体谱分析在 HTLV-1 相关疾病中的应用。
Front Immunol. 2022 Sep 15;13:984274. doi: 10.3389/fimmu.2022.984274. eCollection 2022.

引用本文的文献

1
Progression of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis after Pregnancy: A Case Series and Review of the Literature.人嗜T淋巴细胞病毒1型相关脊髓病/热带痉挛性截瘫在妊娠后的病情进展：病例系列及文献综述
Pathogens. 2024 Aug 28;13(9):731. doi: 10.3390/pathogens13090731.
2
HTLV-1 Proviral Load Absolute RT-qPCR Development for Assessing on Clinical Outcomes in HAM/TSP Patients.用于评估HAM/TSP患者临床结局的HTLV-1前病毒载量绝对定量逆转录-定量聚合酶链反应检测方法的开发
Rep Biochem Mol Biol. 2023 Oct;12(3):393-402. doi: 10.61186/rbmb.12.3.393.
3
Occupational Therapy for People Living With Human T-Lymphotropic Virus 1: Importance and Effectiveness of an Intervention Plan at the Level of Prevention and Rehabilitation.

本文引用的文献

1
Lower numbers of circulating Natural Killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological disease.人类 T 淋巴细胞病毒 1 型（HTLV-1）相关神经疾病患者体内循环自然杀伤 T（NK T）细胞数量减少。
Clin Exp Immunol. 2009 Dec;158(3):294-9. doi: 10.1111/j.1365-2249.2009.04019.x. Epub 2009 Sep 2.
2
IFN-gamma production in response to Tax 161-233, and frequency of CD4+ Foxp3+ and Lin HLA-DRhigh CD123+ cells, discriminate HAM/TSP patients from asymptomatic HTLV-1-carriers in a Peruvian population.针对 Tax 161-233 的 IFN-γ产生情况，以及 CD4+Foxp3+和 Lin HLA-DRhigh CD123+细胞的频率，可将秘鲁人群中的 HAM/TSP 患者与无症状 HTLV-1 携带者区分开来。
Immunology. 2009 Sep;128(1 Suppl):e777-86. doi: 10.1111/j.1365-2567.2009.03082.x. Epub 2009 Feb 17.
3
针对感染人类嗜T淋巴细胞病毒1型者的职业治疗：预防和康复层面干预计划的重要性及有效性
Front Med (Lausanne). 2022 Mar 29;9:859889. doi: 10.3389/fmed.2022.859889. eCollection 2022.
4
An insight to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis; evidence from high-throughput data integration and meta-analysis.对 HTLV-1 相关脊髓病/热带痉挛性截瘫（HAM/TSP）发病机制的深入了解；来自高通量数据集成和荟萃分析的证据。
Retrovirology. 2019 Dec 30;16(1):46. doi: 10.1186/s12977-019-0508-8.
5
Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis.宿主限制因子和人类嗜T淋巴细胞病毒1型（HTLV-1）亚型对HTLV-1相关脊髓病/热带痉挛性截瘫易感性的影响。
Retrovirology. 2017 Apr 19;14(1):26. doi: 10.1186/s12977-017-0350-9.
6
Long-term follow-up of HTLV-1 proviral load in asymptomatic carriers and in incident cases of HAM/TSP: what is its relevance as a prognostic marker for neurologic disease?成人T细胞白血病病毒1型（HTLV-1）无症状携带者和HAM/TSP新发病例的病毒前体负荷长期随访：其作为神经系统疾病预后标志物的相关性如何？
J Neurovirol. 2017 Feb;23(1):125-133. doi: 10.1007/s13365-016-0484-x. Epub 2016 Sep 27.
7
HTLV-1, Immune Response and Autoimmunity.人类嗜T淋巴细胞病毒1型、免疫反应与自身免疫
Viruses. 2015 Dec 24;8(1):5. doi: 10.3390/v8010005.
8
Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis.人类嗜T淋巴细胞病毒1型相关脊髓病/热带痉挛性截瘫的家族聚集性。
PLoS One. 2014 May 6;9(5):e86144. doi: 10.1371/journal.pone.0086144. eCollection 2014.
9
Human T-lymphotropic Virus Type I (HTLV-I) Proviral Load and Clinical Features in Iranian HAM/TSP Patients: Comparison of HTLV-I Proviral Load in HAM/TSP Patients.伊朗HAM/TSP患者中I型人类嗜T淋巴细胞病毒（HTLV-I）前病毒载量及临床特征：HAM/TSP患者中HTLV-I前病毒载量的比较
Iran J Basic Med Sci. 2013 Mar;16(3):268-72.
10
The Impact of Immune Response on HTLV-I in HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).免疫应答对 HTLV-I 相关脊髓病/热带痉挛性截瘫（HAM/TSP）中 HTLV-I 的影响。
Iran J Basic Med Sci. 2013 Mar;16(3):235-41.
Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders.在与人类嗜T淋巴细胞病毒1型（HTLV-1）相关疾病患者中，具有抗HTLV-1活性的恒定自然杀伤T细胞严重缺失。
Blood. 2009 Oct 8;114(15):3208-15. doi: 10.1182/blood-2009-02-203042. Epub 2009 Aug 7.
4
Presentation of human T cell leukemia virus type 1 (HTLV-1) Tax protein by dendritic cells: the underlying mechanism of HTLV-1-associated neuroinflammatory disease.人 T 细胞白血病病毒 1 型 (HTLV-1) Tax 蛋白在树突状细胞中的呈递：HTLV-1 相关神经炎症性疾病的潜在机制。
J Leukoc Biol. 2009 Nov;86(5):1205-16. doi: 10.1189/jlb.0309172. Epub 2009 Aug 5.
5
Accumulation of human T-lymphotropic virus type I (HTLV-I)-infected cells in the cerebrospinal fluid during the exacerbation of HTLV-I-associated myelopathy.人类嗜T淋巴细胞病毒I型（HTLV-I）相关脊髓病加重期脑脊液中HTLV-I感染细胞的积聚。
J Neurovirol. 2008 Oct;14(5):459-63. doi: 10.1080/13550280802178538. Epub 2008 Nov 12.
6
Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy.人类嗜T淋巴细胞病毒I型相关脊髓病中Foxp3表达降低且巨细胞病毒特异性细胞毒性T淋巴细胞增加。
J Neuroimmunol. 2008 Aug 30;200(1-2):115-24. doi: 10.1016/j.jneuroim.2008.06.005. Epub 2008 Jul 18.
7
Impaired function of human T-lymphotropic virus type 1 (HTLV-1)-specific CD8+ T cells in HTLV-1-associated neurologic disease.人类嗜T淋巴细胞病毒1型（HTLV-1）相关神经疾病中HTLV-1特异性CD8 + T细胞功能受损。
Blood. 2008 Sep 15;112(6):2411-20. doi: 10.1182/blood-2008-02-140335. Epub 2008 May 23.
8
Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells.无细胞的1型人嗜T淋巴细胞病毒感染树突状细胞，导致CD4(+) T细胞的传播和转化。
Nat Med. 2008 Apr;14(4):429-36. doi: 10.1038/nm1745. Epub 2008 Mar 23.
9
Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide.利用由神经疾病易感性等位基因及其免疫显性肽组成的主要组织相容性复合体II类四聚体对1型人类嗜T淋巴细胞病毒特异性CD4 +细胞进行体外分析。
J Infect Dis. 2007 Dec 15;196(12):1761-72. doi: 10.1086/522966.
10
High frequency of CD4+FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1-specific CTL response.人类嗜T淋巴细胞病毒1型（HTLV-1）感染中CD4+FoxP3+细胞的高频率：与HTLV-1特异性细胞毒性T淋巴细胞（CTL）反应呈负相关。
Blood. 2008 May 15;111(10):5047-53. doi: 10.1182/blood-2007-10-118539. Epub 2007 Dec 19.