Division of Hematology and Oncology, Department of Medicine, The George Washington University Medical Center, 2150 Pennsylvania Avenue Northwest, Washington, DC 20037, USA.
J Oncol. 2010;2010:361836. doi: 10.1155/2010/361836. Epub 2010 Feb 11.
Angiogenesis has been well recognized as a fundamental part of a multistep process in the evolution of cancer progression, invasion, and metastasis. Strategies for inhibiting angiogenesis have been one of the most robust fields of cancer investigation, focusing on the vascular endothelial growth factor (VEGF) family and its receptors. There are numerous regulatory drug approvals to date for the use of these agents in treating a variety of solid tumors. While therapeutic efficacy has been established, challenges remain with regards to overcoming resistance and assessing response to antiangiogenic therapies. Prostate cancer is the most common noncutaneous malignancy among American men and angiogenesis plays a role in disease progression. The use of antiangiogenesis agents in prostate cancer has been promising and is hereby explored.
血管生成已被充分认识为癌症进展、浸润和转移这一多步骤过程的基本组成部分。抑制血管生成的策略一直是癌症研究中最活跃的领域之一,重点是血管内皮生长因子(VEGF)家族及其受体。迄今为止,已有许多调节药物批准用于治疗各种实体瘤。虽然已经确定了治疗效果,但在克服耐药性和评估抗血管生成治疗反应方面仍存在挑战。前列腺癌是美国男性中最常见的非皮肤恶性肿瘤,血管生成在疾病进展中起作用。抗血管生成药物在前列腺癌中的应用具有广阔前景,在此进行探讨。