Gierek Tatiana, Paluch Jarosław, Pencak Przemysław, Kaźmierczak Beata, Klimczak-Gołab Lucyna
Otolaryngol Pol. 2009 Sep-Oct;63(5):403-6. doi: 10.1016/S0030-6657(09)70151-9.
Diffusion tensor imaging is unique in its ability to non-invasively visualize white matter fiber tracts in the human brain in vivo. White matter fiber bundles of the human brain form a spatial defined by the anatomical and functional architecture. Determination of axonal pathways provides an invaluable means to study the connectivity of human brain and its functional network. Comparison of fiber tract properties across subjects requires comparison at corresponding anatomical locations. In this paper, we present application of white matter tractography method based on incoherent motion of water molecules in fiber tissue, mainly in central nervous system. This motion is itself dependent on the micro-structural environment that restricts the movement of the water molecules. In white matter fibers there is a pronounced directional dependence on diffusion. With white matter fiber tracking or tractography, projections among brain regions can be detected in the three-dimentional diffusion tensor dataset according to the directionality of the fibers. The authors indicate diagnostic possibilities of MR tractography in otolaryngology for imaging the nervous tracts of sense of hearing, smell and taste with particular consideration of otoneurological evaluation of patients with cochlear implants and bone anchored hearing aid (BAHA). White matter tracts can be evaluated independently by using diffusion tensor tractography, which appears to be a promising technique for determining changes in white matter in degenerative disease. The authors also indicate that method as a beneficial in the surgical planning for patients with intrinsic brain tumors.
扩散张量成像的独特之处在于其能够在活体状态下无创地可视化人类大脑中的白质纤维束。人类大脑的白质纤维束形成了一个由解剖学和功能结构所定义的空间。轴突通路的确定为研究人类大脑的连通性及其功能网络提供了一种非常有价值的手段。跨个体比较纤维束特性需要在相应的解剖位置进行比较。在本文中,我们介绍了基于纤维组织中水分子非相干运动的白质纤维束成像方法的应用,主要应用于中枢神经系统。这种运动本身取决于限制水分子运动的微观结构环境。在白质纤维中,扩散存在明显的方向依赖性。通过白质纤维追踪或纤维束成像,可以根据纤维的方向性在三维扩散张量数据集中检测脑区之间的投射。作者指出了磁共振纤维束成像在耳鼻喉科用于听觉、嗅觉和味觉神经束成像的诊断可能性,尤其考虑了对人工耳蜗植入和骨锚式助听器(BAHA)患者的耳神经学评估。白质纤维束可以通过使用扩散张量纤维束成像进行独立评估,这似乎是一种用于确定退行性疾病中白质变化的有前景的技术。作者还指出该方法对原发性脑肿瘤患者的手术规划有益。