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[腮腺及腮腺区转移瘤]

[Metastases to the parotid gland and parotid region].

作者信息

Zyłka Stanisław, Zawadzki Marcin, Bień Stanisław

机构信息

Dział Otorynolaryngologii, Chirurgii Głowy i Szyi Swietokrzyskiego Centrum Onkologii w Kielcach.

出版信息

Otolaryngol Pol. 2009 Sep-Oct;63(5):407-13. doi: 10.1016/S0030-6657(09)70152-0.

Abstract

INTRODUCTION

Among the malignant tumors found within the parotid gland, the primary tumors, as well as a metastatic tumors may be found.

AIM

Epidemiological and clinical characteristic, and preliminary assessment of treatment results of metastatic tumors to the parotid gland and the parotid region.

MATERIAL AND METHODS

The retrospective analysis of 60 cases with metastatic tumors to the parotid gland and parotid region, selected from the material of Dept. ORL H&N Surg. Holy Cross Cancer Center in Kielce - Poland (2001-2008), with the analysis of age, sex, localization and histopathology of primary tumor, stage according to O'Brien classification, diagnostic methods and treatment modalities, and analysis of 3 and 5 years survival.

RESULTS

In the analyzed group of 60 patients (35M + 25F), in the age ranging from 31 to 92 years (mean age 73,5), the most common primary localization of metastatic tumor was skin of the head and neck (Squamous Cell Ca - 41,6%; Malignant Melanoma 25,0%). The therapy with radical intention was applied in 75,0% of patients treated, mostly combined surgery and radiotherapy. 25,0% of patients received symptomatic and palliative treatment only. In the group with 3 (17 cases) and 5 years (6 cases) of observation accordingly, 53,1% and 33,3% total survival was achieved.

CONCLUSIONS

The most common primary localization of metastases to the parotid region are Squamous Cell Carcinoma and Malignant Melanoma of the head and neck skin. Metastases to the parotid gland and region are usually diagnosed in the advanced local stage of the disease. The treatment of choice in mentioned above metastases are surgery followed by radiotherapy. The unfavorable prognosis of metastatic tumors to the parotid gland and parotid region may be improved, with systematic follow up of the patients with the skin cancer.

摘要

引言

在腮腺内发现的恶性肿瘤中,可发现原发性肿瘤以及转移性肿瘤。

目的

腮腺及腮腺区域转移性肿瘤的流行病学和临床特征,以及对治疗结果的初步评估。

材料与方法

回顾性分析从波兰凯尔采圣十字癌症中心耳鼻喉头颈外科材料中选取的60例腮腺及腮腺区域转移性肿瘤病例(2001 - 2008年),分析年龄、性别、原发肿瘤的部位和组织病理学、根据奥布赖恩分类法的分期、诊断方法和治疗方式,并分析3年和5年生存率。

结果

在分析的60例患者(35例男性 + 25例女性)中,年龄在31至92岁之间(平均年龄73.5岁),转移性肿瘤最常见的原发部位是头颈部皮肤(鳞状细胞癌 - 41.6%;恶性黑色素瘤25.0%)。75.0%接受治疗的患者采用了根治性治疗,主要是手术联合放疗。25.0%的患者仅接受了对症和姑息治疗。在分别有3年(17例)和5年(6例)观察期的组中,总生存率分别为53.1%和33.3%。

结论

腮腺区域转移瘤最常见的原发部位是头颈部皮肤的鳞状细胞癌和恶性黑色素瘤。腮腺及腮腺区域的转移瘤通常在疾病的晚期局部阶段被诊断出来。上述转移瘤的首选治疗方法是手术,随后进行放疗。对皮肤癌患者进行系统随访,可能会改善腮腺及腮腺区域转移性肿瘤的不良预后。

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