Komiyama Yutaka, Ikuta Akiko, Ozaki Takae, Munakata Machiko, Nishimura Noriko, Yoshika Masamichi, Yokoi Toyohiko, Masuda Midori, Masaki Hiroya, Horikoshi Yorihiko, Kanzaki Hideharu, Takahashi Hakuo
Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University, Moriguchi 570-8506, Japan.
Rinsho Byori. 2010 Jan;58(1):30-4.
Squamous cell carcinoma antigen (SCCA) is a diagnostic tumor marker for the advanced uterine, cervix and lung tumor. Although SCCA is a prognostic indicator for some tumors, recent progress of this marker has shown that the SCCA could also be found in the serum of nonmalignant disease such as renal failure and others. Here, we report a case of spuriously high level of SCCA in patient without carcinoma, renal failure, head-and-neck disease and lung disease. An early fifties female who had been undergone the diagnostic conization for high-grade cervical intraepithelial neoplasia ten years ago and observed without special treatment with around 20ng/ml level of SCCA. She has no signs of tumor, renal failure, head-and-neck disease or lung disease until now. The high performance liquid chromatography with Superdex 200 showed the molecular weight of the major part of SCCA of the patient is more than 160 kDa and the part of 45 kDa, the same molecular weight as lung tumor, is trace amount. Moreover, the ultrafiltration analysis showed the SCCA of the present case did not penetrate the 100 kDa cut-filter, but SCCAs with other patients with uterine, cervix, lung tumor and renal failure did penetrate the filter. In this case, the analysis of molecular weight of SCCA using HPLC gel filtration and ultrafiltration is useful to rule out spuriously elevated SCCA.
鳞状细胞癌抗原（SCCA）是晚期子宫、宫颈和肺癌的诊断性肿瘤标志物。尽管SCCA是某些肿瘤的预后指标，但该标志物的最新研究进展表明，在肾衰竭等非恶性疾病患者的血清中也可检测到SCCA。在此，我们报告一例无癌症、肾衰竭、头颈疾病和肺部疾病患者SCCA水平假性升高的病例。一名五十出头的女性，十年前因高级别宫颈上皮内瘤变接受了诊断性锥切术，此后一直未接受特殊治疗，SCCA水平约为20ng/ml。截至目前，她没有肿瘤、肾衰竭、头颈疾病或肺部疾病的迹象。使用Superdex 200的高效液相色谱法显示，该患者SCCA主要部分的分子量超过160 kDa，而与肺癌分子量相同的45 kDa部分含量极少。此外，超滤分析表明，本例患者的SCCA不能透过100 kDa的截留滤膜，但子宫、宫颈、肺癌和肾衰竭患者的SCCA能够透过该滤膜。在这种情况下，利用高效液相色谱凝胶过滤和超滤分析SCCA的分子量，有助于排除SCCA的假性升高。
