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Further analysis of correlates of protection from a phase 2a trial of the falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults.

作者信息

Olotu Ally Ibrahim, Fegan Gregory, Bejon Philip

出版信息

J Infect Dis. 2010 Mar 15;201(6):970-1. doi: 10.1086/651025.

DOI:10.1086/651025
PMID:20170369
Abstract
摘要

相似文献

1
Further analysis of correlates of protection from a phase 2a trial of the falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults.对恶性疟原虫疫苗RTS,S/AS01B和RTS,S/AS02A在未感染疟疾的成年人中进行的2a期试验中保护相关因素的进一步分析。
J Infect Dis. 2010 Mar 15;201(6):970-1. doi: 10.1086/651025.
2
Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection.恶性疟原虫疟疾疫苗RTS,S/AS01B和RTS,S/AS02A在未感染疟疾成年人中的随机、双盲、2a期试验：安全性、有效性及保护的免疫相关因素
J Infect Dis. 2009 Aug 1;200(3):337-46. doi: 10.1086/600120.
3
Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A.新型佐剂配方改善疟疾疫苗RTS,S/AS02A免疫原性的临床前评估
Vaccine. 2006 Oct 30;24(42-43):6483-92. doi: 10.1016/j.vaccine.2006.06.033. Epub 2006 Jul 3.
4
Safety and immunogenicty of RTS,S/AS02A candidate malaria vaccine in Gambian children.RTS,S/AS02A候选疟疾疫苗在冈比亚儿童中的安全性和免疫原性。
Vaccine. 2005 Jul 14;23(32):4148-57. doi: 10.1016/j.vaccine.2005.03.019. Epub 2005 Apr 15.
5
Heterologous prime-boost immunization in rhesus macaques by two, optimally spaced particle-mediated epidermal deliveries of Plasmodium falciparum circumsporozoite protein-encoding DNA, followed by intramuscular RTS,S/AS02A.在恒河猴中进行异源初免-加强免疫，先通过两次间隔最佳的颗粒介导的表皮递送编码恶性疟原虫环子孢子蛋白的DNA，然后进行肌肉注射RTS,S/AS02A。
Vaccine. 2006 May 8;24(19):4167-78. doi: 10.1016/j.vaccine.2006.02.041. Epub 2006 Mar 6.
6
Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomised controlled trial.RTS,S/AS02A疟疾疫苗预防莫桑比克儿童恶性疟原虫病的保护期：一项随机对照试验的单盲延长随访
Lancet. 2005 Dec 10;366(9502):2012-8. doi: 10.1016/S0140-6736(05)67669-6.
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Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine.RTS,S/SBAS2（一种重组恶性疟原虫疟疾疫苗）可有效诱导针对性的Th1型细胞免疫和体液免疫反应。
J Infect Dis. 1999 Nov;180(5):1656-64. doi: 10.1086/315074.
8
Long-term safety and efficacy of the RTS,S/AS02A malaria vaccine in Mozambican children.RTS,S/AS02A疟疾疫苗在莫桑比克儿童中的长期安全性和有效性
J Infect Dis. 2009 Aug 1;200(3):329-36. doi: 10.1086/600119.
9
Cutaneous delayed-type hypersensitivity (DTH) in a multi-formulation comparator trial of the anti-falciparum malaria vaccine candidate RTS,S in rhesus macaques.恒河猴中抗恶性疟原虫疫苗候选物RTS,S多配方对照试验中的皮肤迟发型超敏反应（DTH）
Vaccine. 2006 Oct 30;24(42-43):6493-502. doi: 10.1016/j.vaccine.2006.06.035. Epub 2006 Jul 5.
10
Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research.在沃尔特·里德陆军研究所，针对未感染疟疾的成年人，开展了疟疾疫苗RTS,S/AS02的0、1和3个月以及0、7和28天免疫接种计划的2a期试验。
Vaccine. 2008 Apr 24;26(18):2191-202. doi: 10.1016/j.vaccine.2008.02.048. Epub 2008 Mar 13.

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Modelling the roles of antibody titre and avidity in protection from Plasmodium falciparum malaria infection following RTS,S/AS01 vaccination.建模 RTS,S/AS01 疫苗接种后抗体效价和亲和力在预防恶性疟原虫疟疾感染中的作用。
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Robust antibody and CD8 T-cell responses induced by CSP adsorbed to cationic liposomal adjuvant CAF09 confer sterilizing immunity against experimental rodent malaria infection.
吸附于阳离子脂质体佐剂CAF09的环孢子蛋白（CSP）诱导的强大抗体和CD8 T细胞反应赋予针对实验性啮齿动物疟疾感染的无菌免疫。
NPJ Vaccines. 2017;2. doi: 10.1038/s41541-017-0011-y. Epub 2017 Apr 10.
4
Characterization of T-cell immune responses in clinical trials of the candidate RTS,S malaria vaccine.临床试验中候选疟疾疫苗 RTS,S 的 T 细胞免疫应答特征。
Hum Vaccin Immunother. 2018 Jan 2;14(1):17-27. doi: 10.1080/21645515.2017.1381809. Epub 2017 Dec 1.
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Antigen capsid-display on human adenovirus 35 via pIX fusion is a potent vaccine platform.通过pIX融合在人腺病毒35上展示抗原衣壳是一种有效的疫苗平台。
PLoS One. 2017 Mar 31;12(3):e0174728. doi: 10.1371/journal.pone.0174728. eCollection 2017.
6
Ad35.CS.01-RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults.Ad35.CS.01-RTS,S/AS01异源初免-加强疫苗对未感染疟疾的健康成年人子孢子攻击的疗效。
PLoS One. 2015 Jul 6;10(7):e0131571. doi: 10.1371/journal.pone.0131571. eCollection 2015.
7
Avidity of anti-circumsporozoite antibodies following vaccination with RTS,S/AS01E in young children.幼儿接种RTS,S/AS01E疫苗后抗环子孢子抗体的亲和力
PLoS One. 2014 Dec 15;9(12):e115126. doi: 10.1371/journal.pone.0115126. eCollection 2014.
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The relationship between RTS,S vaccine-induced antibodies, CD4⁺ T cell responses and protection against Plasmodium falciparum infection.RTS,S 疫苗诱导的抗体、CD4+T 细胞应答与抗疟原虫感染的关系。
PLoS One. 2013 Apr 16;8(4):e61395. doi: 10.1371/journal.pone.0061395. Print 2013.
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