Different fetal-neonatal outcomes in siblings born to a mother with Graves-Basedow disease after total thyroidectomy: a case series.

作者信息

Zuppa Antonio Alberto, Sindico Paola, Perrone Sabrina, Carducci Chiara, Antichi Eleonora, Alighieri Giovanni, Cota Francesco, Papacci Patrizia, De Carolis Maria Pia, Romagnoli Costantino, Cardiello Valentina

机构信息

Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Largo Agostino Gemelli 8, 00168 Rome, Italy.

出版信息

J Med Case Rep. 2010 Feb 19;4:59. doi: 10.1186/1752-1947-4-59.

INTRODUCTION

We describe three different fetal or neonatal outcomes in the offspring of a mother who had persistent circulating thyrotropin receptor antibodies despite having undergone a total thyroidectomy several years before.

CASE PRESENTATION

The three different outcomes were an intrauterine death, a mild and transient fetal and neonatal hyperthyroidism and a severe fetal and neonatal hyperthyroidism that required specific therapy.

CONCLUSIONS

The three cases are interesting because of the different outcomes, the absence of a direct correlation between thyrotropin receptor antibody levels and clinical signs, and the persistence of thyrotropin receptor antibodies several years after a total thyroidectomy.