一位患格雷夫斯-巴塞多氏病的母亲在全甲状腺切除术后所生孩子的不同胎儿-新生儿结局：病例系列
Different fetal-neonatal outcomes in siblings born to a mother with Graves-Basedow disease after total thyroidectomy: a case series.
作者信息
Zuppa Antonio Alberto, Sindico Paola, Perrone Sabrina, Carducci Chiara, Antichi Eleonora, Alighieri Giovanni, Cota Francesco, Papacci Patrizia, De Carolis Maria Pia, Romagnoli Costantino, Cardiello Valentina
机构信息
Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Largo Agostino Gemelli 8, 00168 Rome, Italy.
出版信息
J Med Case Rep. 2010 Feb 19;4:59. doi: 10.1186/1752-1947-4-59.
INTRODUCTION
We describe three different fetal or neonatal outcomes in the offspring of a mother who had persistent circulating thyrotropin receptor antibodies despite having undergone a total thyroidectomy several years before.
CASE PRESENTATION
The three different outcomes were an intrauterine death, a mild and transient fetal and neonatal hyperthyroidism and a severe fetal and neonatal hyperthyroidism that required specific therapy.
CONCLUSIONS
The three cases are interesting because of the different outcomes, the absence of a direct correlation between thyrotropin receptor antibody levels and clinical signs, and the persistence of thyrotropin receptor antibodies several years after a total thyroidectomy.
引言
我们描述了一位母亲的后代出现的三种不同的胎儿或新生儿结局。这位母亲尽管在几年前接受了全甲状腺切除术，但仍存在持续循环的促甲状腺素受体抗体。
病例报告
三种不同的结局分别为宫内死亡、轻度短暂的胎儿及新生儿甲状腺功能亢进症以及需要特殊治疗的严重胎儿及新生儿甲状腺功能亢进症。
结论
这三个病例很有意思，原因在于结局不同、促甲状腺素受体抗体水平与临床体征之间缺乏直接关联以及全甲状腺切除术后数年促甲状腺素受体抗体仍持续存在。
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