Evers Annemieke C C, van Leeuwen Jeanette, Kwee Anneke, Brouwers Hens A A, Koopman-Esseboom Corine, Nikkels Peter G J, Duyn Annette, Bruinse Hein W
Universitair Medisch Centrum Utrecht, locatie Wilhelmina Kinderziekenhuis, divisie Vrouw en Baby, Utrecht, The Netherlands.
Ned Tijdschr Geneeskd. 2010;154:A118.
To gain an insight into perinatal mortality and morbidity in full-term infants without congenital abnormalities admitted to a neonatal intensive care unit (NICU).
Retrospective analysis.
In this study, all full-term infants, who were born in the period 1997-2003 without congenital disorders and admitted to the NICU at the Wilhelmina Children's Hospital in Utrecht, the Netherlands were included. Information about the delivery, NICU-admission and follow-up until the age of 18 months was obtained from the hospital charts.
In total 597 full-term neonates were admitted to the NICU during the study period; this is equivalent to 3-4 per 1,000 full-term neonates in the Utrecht region. Of these, 47% were admitted on account of asphyxia, 17% with respiratory problems and 12% with infections. In 79% of all NICU admissions the delivery had taken place under secondary care; in 29% labour had started under exclusive care of a primary level midwife, because the pregnancy had been defined as low-risk. 21% of the neonates were admitted to the NICU following delivery under exclusive primary care. Almost 15% of the infants died in the NICU, in 89% due to asphyxia. Of the surviving infants following perinatal asphyxia, 15% had a permanent disability at the age of 18 months.
Post-partum admission of a fundamentally healthy full-term neonate to the NICU is a serious adverse perinatal outcome, and warrants further investigation. The various factors that influence these admissions should be analysed in more detail, for instance by means of perinatal audits.
深入了解入住新生儿重症监护病房(NICU)的无先天性异常足月婴儿的围产期死亡率和发病率。
回顾性分析。
本研究纳入了1997年至2003年期间在荷兰乌得勒支的威廉明娜儿童医院出生且无先天性疾病并入住NICU的所有足月婴儿。从医院病历中获取了有关分娩、入住NICU及直至18个月龄随访的信息。
在研究期间,共有597名足月新生儿入住NICU;这相当于乌得勒支地区每1000名足月新生儿中有3 - 4名。其中,47%因窒息入院,17%因呼吸问题入院,12%因感染入院。在所有入住NICU的病例中,79%的分娩是在二级护理下进行的;29%的分娩是在初级助产士的专属护理下开始的,因为该妊娠被定义为低风险。21%的新生儿是在专属初级护理下分娩后入住NICU的。近15%的婴儿在NICU死亡,其中89%是由于窒息。在围产期窒息后存活的婴儿中,15%在18个月龄时存在永久性残疾。
将基本健康的足月新生儿产后送入NICU是一种严重的不良围产期结局,值得进一步研究。应更详细地分析影响这些入院情况的各种因素,例如通过围产期审计。