Bayazit Yildirim A, Celenk F, Gunduz A G, Gunduz B, Ondag N, Meray J
Department of Otorhinolaryngology, Faculty of Medicine, Gazi University, Besevler, Cankaya, Ankara, Turkey.
J Laryngol Otol. 2010 Jun;124(6):610-5. doi: 10.1017/S0022215110000010. Epub 2010 Feb 22.
To assess vestibular evoked myogenic potentials in patients with fibromyalgia syndrome.
Twenty-four patients with fibromyalgia syndrome (two men and 22 women) and 21 female controls were included in the study. All patients underwent vestibular evoked myogenic potential testing.
Statistical comparison of fibromyalgia patients with control subjects showed a significant difference with respect to n23 latencies and interpeak latencies (p < 0.05). There was no significant difference in p13 latencies, nor in p13 amplitudes, n23 amplitudes or interpeak amplitudes (p > 0.05).
Although patients with fibromyalgia syndrome generally have subjective neurotological symptoms, clinical and laboratory assessments usually fail to detect any objective abnormality. However, it is possible to detect abnormalities on vestibular evoked myogenic potential testing in such patients, indicating dysfunction in the vestibulospinal pathway, possibly in the saccule. Elongation of the n23 latency and of the interpeak latency of waves p13-n23, during vestibular evoked myogenic potential testing, may be a useful, objective indicator demonstrating neurotological involvement in fibromyalgia syndrome patients. Future research investigating the mechanisms of this latency elongation may help increase understanding of the pathogenesis of fibromyalgia syndrome.
评估纤维肌痛综合征患者的前庭诱发肌源性电位。
本研究纳入了24例纤维肌痛综合征患者（2名男性和22名女性）以及21名女性对照者。所有患者均接受了前庭诱发肌源性电位测试。
纤维肌痛患者与对照者的统计学比较显示，在n23潜伏期和峰间潜伏期方面存在显著差异（p < 0.05）。p13潜伏期、p13波幅、n23波幅或峰间波幅均无显著差异（p > 0.05）。
尽管纤维肌痛综合征患者通常有主观的神经耳科症状，但临床和实验室评估通常无法检测到任何客观异常。然而，在此类患者的前庭诱发肌源性电位测试中有可能检测到异常，这表明前庭脊髓通路存在功能障碍，可能在内耳球囊。在前庭诱发肌源性电位测试期间，n23潜伏期以及p13 - n23波的峰间潜伏期延长，可能是一个有用的客观指标，表明纤维肌痛综合征患者存在神经耳科受累情况。未来研究该潜伏期延长的机制可能有助于增进对纤维肌痛综合征发病机制的理解。
