Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 29208, USA.
Behav Brain Res. 2011 Aug 10;221(2):527-36. doi: 10.1016/j.bbr.2010.02.022. Epub 2010 Feb 16.
Acetylcholine release links the activity of presynaptic neurons with their postsynaptic targets and thus represents the intercellular correlate of cholinergic neurotransmission. Here, we review the regulation and functional significance of acetylcholine release in the mammalian cerebral cortex, with a particular emphasis on information derived from in vivo microdialysis studies over the past three decades. This information is integrated with anatomical and behavioral data to derive conclusions regarding the role of cortical cholinergic transmission in normal behavioral and how its dysregulation may contribute to cognitive correlates of several neuropsychiatric conditions. Some unresolved issues regarding the regulation and significance of cortical acetylcholine release and the promise of new methodology for advancing our knowledge in this area are also briefly discussed.
乙酰胆碱释放将突触前神经元的活动与其突触后靶标联系起来，因此代表了胆碱能神经传递的细胞间相关性。在这里，我们回顾了哺乳动物大脑皮层中乙酰胆碱释放的调节和功能意义，特别强调了过去三十年中来自体内微透析研究的信息。这些信息与解剖学和行为数据相结合，得出了关于皮质胆碱能传递在正常行为中的作用的结论，以及其失调如何导致几种神经精神疾病的认知相关的结论。本文还简要讨论了关于皮质乙酰胆碱释放的调节和意义的一些未解决的问题，以及新方法在该领域推进我们的知识的前景。
