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淋巴管畸形:一种建议的管理算法。

Lymphatic malformations: a proposed management algorithm.

作者信息

Oosthuizen J C, Burns P, Russell J D

机构信息

Our Lady's Hospital for Sick Children, Crumlin, Dublin, D12, Republic of Ireland.

出版信息

Int J Pediatr Otorhinolaryngol. 2010 Apr;74(4):398-403. doi: 10.1016/j.ijporl.2010.01.013. Epub 2010 Feb 18.

Abstract

OBJECTIVE

The aim of this study was to develop a management algorithm for cervicofacial lymphatic malformations, based on the authors' experience in managing these lesions as well as current literature on the subject.

STUDY DESIGN AND METHODS

A retrospective medical record review of all the patients treated for lymphatic malformations at our institution during a 10-year period (1998-2008) was performed.

DATA COLLECTED

age at diagnosis, location and type of lesion, radiologic investigation performed, presenting symptoms, treatment modality used, complications and results achieved.

RESULTS

14 patients were identified. Eight (57%) male and six (43%) female. There was an equal distribution between the left and right sides. The majority (71%) of cases were diagnosed within the first year of life. The majority of lesions were located in the suprahyoid region. The predominant reason for referral was an asymptomatic mass in 7 cases (50%) followed by airway compromise (36%) and dysphagia (14%). Management options employed included: observation, OK-432 injection, surgical excision and laser therapy. In 5 cases (36%) a combination of these were used.

CONCLUSION

Historically surgical excision has been the management option of choice for lymphatic malformations. However due to the morbidity and high complication rate associated this is increasingly being questioned. Recent advances in sclerotherapy e.g. OK-432 injection have also shown significant promise. Based on experience in managing these lesions as well as current literature the authors of this paper have developed an algorithm for the management of cervicofacial lymphatic malformations.

摘要

目的

本研究旨在根据作者对这些病变的管理经验以及该主题的当前文献,制定一种针对头颈部淋巴管瘤的管理算法。

研究设计与方法

对我们机构在10年期间(1998 - 2008年)接受淋巴管瘤治疗的所有患者进行回顾性病历审查。

收集的数据

诊断时的年龄、病变的位置和类型、进行的放射学检查、出现的症状、使用的治疗方式、并发症及取得的结果。

结果

共确定14例患者。男性8例(57%),女性6例(43%)。左右两侧分布均衡。大多数病例(71%)在出生后第一年内被诊断出来。大多数病变位于舌骨上区域。转诊的主要原因是7例(50%)无症状肿块,其次是气道受压(36%)和吞咽困难(14%)。采用的管理方案包括:观察、注射OK - 432、手术切除和激光治疗。5例(36%)采用了这些方法的联合应用。

结论

从历史上看,手术切除一直是淋巴管瘤的首选管理方案。然而,由于与之相关的发病率和高并发症率,这一方案越来越受到质疑。硬化疗法的最新进展,如注射OK - 432,也显示出显著的前景。基于对这些病变的管理经验以及当前文献,本文作者制定了一种头颈部淋巴管瘤的管理算法。

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