新型鸢尾酮衍生物的设计、合成及作为脑缺血潜在神经保护剂的生物学评价。
Design, synthesis and biological evaluation of new ionone derivatives as potential neuroprotective agents in cerebral ischemia.
机构信息
Medicinal & Process Chemistry Division, Central Drug Research Institute, CSIR, Chattar Manzil Palace, Lucknow 226001, UP, India.
出版信息
Eur J Med Chem. 2010 May;45(5):1964-71. doi: 10.1016/j.ejmech.2010.01.039. Epub 2010 Jan 28.
PMID:20170988
Abstract
A new series of ionone derived allylic alcohols have been evaluated for anti-ischemic activity. Out of them, 12f and 13b decreased infarct volume to 23.98+/-4.7 mm3 and 93.98+/-24.8 mm3 as compared to ischemic group.
摘要
已评估了一系列新型的紫罗兰酮衍生烯丙醇类化合物的抗缺血活性。其中，12f 和 13b 使梗死体积分别减少至 23.98+/-4.7 mm3 和 93.98+/-24.8 mm3，与缺血组相比。
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