Department of Clinical Sciences, Section of Women's Health Sciences, Università Politecnica Marche, Ancona, Italy.
Med Hypotheses. 2010 Jul;75(1):38-46. doi: 10.1016/j.mehy.2010.01.024. Epub 2010 Feb 18.
Normal gestation implants on a relatively hypoxic deciduas so that trophoblast deeply invades endometrium and angiogenesis seeks for oxygen supply. If implantation occurs before those hypoxic conditions occur, trophoblast invasion is defective, due to the relatively high oxygen tension in the decidual environment, laying the foundations for subsequent pre-eclampsia.
正常妊娠时，胎盘会植入相对缺氧的蜕膜中，使滋养细胞深入侵袭子宫内膜并寻找血管生成以获取氧气供应。如果植入发生在这些缺氧条件出现之前，由于蜕膜环境中的氧气张力相对较高，滋养细胞的侵袭会出现缺陷，为随后的子痫前期奠定基础。
