长链 2H-氮丙啶-羧酸酯类化合物的合成及与地昔硝唑相关的链依赖性抗真菌活性。
Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
机构信息
Department of Chemistry and Biochemistry, San Diego, La Jolla, CA 92093, USA.
出版信息
Bioorg Med Chem Lett. 2010 Mar 15;20(6):2029-32. doi: 10.1016/j.bmcl.2010.01.068. Epub 2010 Feb 1.
Abstract
Analogues of the antifungal marine natural product (E)-dysidazirine were prepared and evaluated in broth ro-dilution assays against a panel of fungal pathogens. A simple structure-activity relationship was developed which provides insight into the mechanism of action of long-chain 2H-azirine carboxylates.
摘要
合成了抗真菌海洋天然产物 (E)-dysidazirine 的类似物，并在肉汤稀释测定中对一系列真菌病原体进行了评估。建立了一个简单的构效关系，该关系深入了解了长链 2H-氮丙啶羧酸酯的作用机制。
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