Smith B R, Pyle G A, Petersen V B, Hall R
J Endocrinol. 1977 Dec;75(3):401-7. doi: 10.1677/joe.0.0750401.
Thyroid-stimulating antibodies (TSAb) were found to inhibit the binding of labelled thyrotrophin (TSH) to thyroid membranes in a dose-dependent manner and this effect was localized in the Fab part of the TSAb molecule. Analysis of the binding data suggested that TSAb and TSH bound to the same receptor site. Production of cyclic AMP by the thyroid membranes was stimulated by TSAb and TSAb-Fab with a similar time course to that observed with TSH. Kinetic studies indicated that the binding of TSAb to the thyroid membranes was not rate-limiting in the process of stimulation of cyclic AMP production.
甲状腺刺激抗体（TSAb）被发现能以剂量依赖的方式抑制标记促甲状腺素（TSH）与甲状腺膜的结合，且这种效应定位于TSAb分子的Fab部分。结合数据的分析表明，TSAb和TSH结合到相同的受体位点。TSAb和TSAb-Fab刺激甲状腺膜产生环磷酸腺苷（cAMP），其时间进程与TSH相似。动力学研究表明，在刺激cAMP产生的过程中，TSAb与甲状腺膜的结合不是限速步骤。
