Université René Descartes, Service de Chirurgie Cardio-Vasculaire, Assistance Publique-hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Ann Thorac Surg. 2010 Mar;89(3):768-72. doi: 10.1016/j.athoracsur.2009.12.022.
Stent deployment within stenotic native aortic valves has been shown to depend on valve anatomy (presence of bicuspid valve or not). This study investigated the influence of stent stiffness on stent expansion.
The study included 88 patients with severe aortic stenosis, and 36 (41%) had bicuspid aortic valves. Two self-expandable stents with different radial force were deployed intraoperatively inside stenotic aortic valves before surgical aortic valve replacement. Patients in group B received a stent stiffer than that in group A. Effect of stent radial force on stent shape and incidence of paraprosthetic gaps was determined.
Noncircular stent deployment was more frequent in bicuspid (81%) than in tricuspid aortic valves (33%; p < 0.0001). Increasing stent radial force significantly improved stent shape in tricuspid valves (circular shape: 60% in group A vs 93% in group B; p = 0.005) but had no significant effect in bicuspid valves (12.5% in group A vs 27% in group B;p = 0.394). Likewise, incidence of paraprosthetic gaps was significantly reduced with the stiff stent in tricuspid valves (64% in group A vs 30% in group B, p = 0.025) but not in bicuspid valves (50% in group A vs 60% in group B; p= 0.722).
Increased stent radial force had a favorable effect on stent deployment in tricuspid but not in bicuspid valves. In bicuspid valves, stent maldeployment was constant. Leaflet distortion of implanted valved stent might be a concern in this setting.
在狭窄的原生主动脉瓣内植入支架的情况取决于瓣解剖结构(是否存在二叶式主动脉瓣)。本研究旨在探讨支架硬度对支架扩张的影响。
本研究纳入了 88 例严重主动脉瓣狭窄患者,其中 36 例(41%)为二叶式主动脉瓣。在主动脉瓣置换术之前,通过手术将两种具有不同径向力的自膨式支架植入狭窄的主动脉瓣内。B 组患者接受的支架硬度大于 A 组。确定支架径向力对支架形状和瓣周漏的影响。
二叶式主动脉瓣(81%)中非圆形支架植入比三叶式(33%)更常见(p<0.0001)。增加支架径向力可显著改善三叶式主动脉瓣的支架形状(圆形:A 组 60%,B 组 93%;p=0.005),但对二叶式主动脉瓣无显著影响(A 组 12.5%,B 组 27%;p=0.394)。同样,在三叶式主动脉瓣中,硬支架可显著减少瓣周漏的发生(A 组 64%,B 组 30%;p=0.025),但在二叶式主动脉瓣中无显著影响(A 组 50%,B 组 60%;p=0.722)。
增加支架的径向力对三尖瓣支架植入有有利影响,但对二叶式主动脉瓣无影响。在二叶式主动脉瓣中,支架的植入位置不变。在这种情况下,植入瓣叶支架的瓣叶变形可能是一个问题。