Zaoualí M A, Mosbah I Ben, Abdennebi H Ben, Calvo M, Boncompagni E, Boillot O, Peralta C, Roselló-Catafau J
Instituto de Investigaciones Biomédicas de Barcelona, CSIC-IDIBAPS, Barcelona, Spain.
Transplant Proc. 2010 Jan-Feb;42(1):159-61. doi: 10.1016/j.transproceed.2009.12.035.
Institute Georges Lopez preservation solution (IGL-1) has been demonstrated to be useful for fatty liver preservation. The mechanisms responsible for this effective graft protection against ischemia-reperfusion injury are pivotal actions on generation of nitric oxide a diffusible molecule with vasodilator properties, that facilitates the up-regulation of other well-known cytoprotective genes, such as hypoxia-inducible factor-1 alpha (HIF-1alpha) and heme-oxygenase 1 (HO-1). During normoxic reperfusion, the presence of nitric oxide permits HIF-1alpha accumulation to inhibit prolyl-hydoxylases, thus promoting an additional overexpression of the HO-1 in steatotic and nonsteatotic graft livers preserved in IGL-1.
乔治·洛佩斯研究所保存液（IGL-1）已被证明对脂肪肝保存有用。这种有效保护移植物免受缺血再灌注损伤的机制关键在于对一氧化氮生成的作用，一氧化氮是一种具有血管舒张特性的可扩散分子，它促进其他知名细胞保护基因的上调，如缺氧诱导因子-1α（HIF-1α）和血红素加氧酶1（HO-1）。在常氧再灌注期间，一氧化氮的存在使HIF-1α积累以抑制脯氨酰羟化酶，从而促进在IGL-1中保存的脂肪变性和非脂肪变性移植肝脏中HO-1的额外过度表达。
