Petrone H, Arriola M, Re L, Taylor F, Bruzzone M, Chiurchu C, Schiavelli R
Unidad de Trasplante Renal CRAI SUR CUCAIBA, La Plata, Argentina.
Transplant Proc. 2010 Jan-Feb;42(1):288-90. doi: 10.1016/j.transproceed.2009.12.053.
Anemia is prevalent in kidney transplant recipients and likely contributes to morbidity and mortality. The definition of anemia as established by the World Health Organization and subsequently adopted by the American Society of Transplantation is a hemoglobin concentration of 12 g/dL or less in women and 13 g/dL or less in men. Using this definition, the prevalence of anemia is nearly 30%. The National Survey of Post Transplant Anemia (PTA) in kidney transplant recipients in Argentina was conducted to evaluate the incidence of PTA at 1 year and its relationship to variables that influence transplantation outcome. At 1 year posttransplantation, mean (SD) hemoglobin concentration was 12.43 (1.77) g/dL (n = 379), hematocrit concentration was 38.26% (5.59%) (n = 379), serum creatinine concentration was 1.51 (0.72) mg/dL (n = 380), and creatinine clearance was 60.8 (22.47) mL/min (n = 334). The prevalence of PTA in Argentina at 1 year posttransplantation was 42.25%. At univariate analysis, female sex, immunosuppression regimen (mycophenolate mofetil plus mammalian target of rapamycin), and pediatric age group were associated with anemia. At multivariate analysis, only renal function and pediatric age group were associated with anemia. The mean hemoglobin level at year of transplant was 12.43 g/dL +/-1.77 and the prevalence of PTA in Argentina at year of transplant is 42.25%. Results of our survey show a correlation between Hb levels and graft function and pediatric recipient.
贫血在肾移植受者中很常见，可能会导致发病和死亡。世界卫生组织确定并随后被美国移植学会采用的贫血定义为女性血红蛋白浓度低于12 g/dL，男性低于13 g/dL。按照这个定义，贫血的患病率接近30%。阿根廷对肾移植受者进行了移植后贫血（PTA）全国调查，以评估1年时PTA的发生率及其与影响移植结果的变量之间的关系。移植后1年时，平均（标准差）血红蛋白浓度为12.43（1.77）g/dL（n = 379），血细胞比容浓度为38.26%（5.59%）（n = 379），血清肌酐浓度为1.51（0.72）mg/dL（n = 380），肌酐清除率为60.8（22.47）mL/min（n = 334）。阿根廷移植后1年时PTA的患病率为42.25%。单因素分析显示，女性、免疫抑制方案（霉酚酸酯加雷帕霉素作用靶点）和儿童年龄组与贫血相关。多因素分析显示，只有肾功能和儿童年龄组与贫血相关。移植当年的平均血红蛋白水平为12.43 g/dL±1.77，阿根廷移植当年PTA的患病率为42.25%。我们的调查结果显示血红蛋白水平与移植肾功能及儿童受者之间存在相关性。
