Guebre-Egziabher Fitsum, Juillard Laurent, Kalbacher Emilie, Bachetta Justine, Fouque Denis
INSERM U, Lyon, France.
Nephrol Ther. 2010 Feb;6 Suppl 1:S7-12. doi: 10.1016/S1769-7255(10)70005-5.
Chronic renal disease is a state of microinflammation and insulin resistance. They both impact on the patient's outcome with an increased cardiovascular morbi-mortality and malnutrition. Current evidence suggests that there is a link between these two abnormal conditions. Recent data show a multiple organ regulatory pathway with a key role of bone, adipose tissue, immune system and central nervous system in energy balance control and glucose homeostasis. Thus, in searching for effective therapies, we should use an integrated approach aimed at modifying integrated outcomes rather than targeting single molecules.
