Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Box 7035, SE-750 07 Uppsala, Sweden.
Theriogenology. 2010 May;73(8):1068-75. doi: 10.1016/j.theriogenology.2010.01.006. Epub 2010 Feb 20.
Normal labor is accompanied by sequential changes in blood concentrations of prostaglandin F2alpha (measured as 15-ketodihydro-PGF2 alpha=PGFM), progesterone, estradiol, oxytocin, vasopressin, and of elevated cortisol levels. The aim of this study was to investigate hormone concentrations in dogs diagnosed with primary uterine inertia before and during treatment by cesarean section. The hypothesis was the dogs would have abnormally low plasma concentrations in one or several of the hormones involved in parturition. The study comprised seven bitches with total primary uterine inertia (dystocia group) treated with cesarean section and six healthy bitches (control group) subjected to planned cesarean section. Blood samples were taken before anesthesia, before surgery started, on delivery of the first puppy and on delivery of the last puppy. The progesterone:PGFM ratio in plasma was higher in the dystocia group than in the control group, but the serum estradiol concentration did not differ between groups. The plasma concentrations of oxytocin and vasopressin increased in both groups when the first puppies were delivered, but both hormones were more elevated in the control group than in the dystocia group on delivery of the last puppies. The plasma cortisol concentration increased to the same level in both groups. In conclusion, the ratio between progesterone and PGFM was higher and the oxytocin and vasopressin concentrations lower in the dystocia dogs than in the control dogs. The findings indicate that these hormones are involved in the pathophysiology of total primary uterine inertia in bitches.
正常分娩伴随着前列腺素 F2alpha（以 15-酮基二氢-PGF2 alpha=PGFM 测量）、孕酮、雌二醇、催产素、血管加压素和皮质醇水平的顺序变化。本研究旨在调查诊断为原发性子宫无力的犬在剖宫产术前和术中和激素浓度。假设这些狗在参与分娩的一种或几种激素中会出现异常低的血浆浓度。该研究包括 7 只患有完全原发性子宫无力（难产组）的母犬接受剖宫产术治疗和 6 只健康母犬（对照组）接受计划剖宫产术。在麻醉前、手术开始前、第一只幼犬分娩时和最后一只幼犬分娩时采集血样。难产组的血浆孕酮：PGFM 比值高于对照组，但两组间血清雌二醇浓度无差异。两组的催产素和血管加压素血浆浓度在第一只幼犬分娩时均升高，但在最后一只幼犬分娩时对照组的浓度均高于难产组。血浆皮质醇浓度在两组均升高至相同水平。总之，难产犬的孕酮与 PGFM 比值较高，催产素和血管加压素浓度较低。这些发现表明，这些激素参与了犬完全原发性子宫无力的病理生理学。
