Victorian Institute of Forensic Medicine, Department of Forensic Medicine, Monash University, Victoria, Australia.
Forensic Sci Int. 2010 May 20;198(1-3):110-7. doi: 10.1016/j.forsciint.2010.01.014. Epub 2010 Feb 20.
Serotonin-active drugs are detected relatively frequently in Victorian deaths. During 2002-2008, there were 1123 fatalities where one or more of the serotonin-active drugs tramadol, venlafaxine, fluoxetine, sertraline, citalopram, paroxetine and MDMA, were detected. These deaths were reviewed using pathology, toxicology and police reports, to determine the contribution of these drugs to the cause of death, particularly if serotonin toxicity was the mechanism of death. There were 28 cases of most interest to this research because of the presence of the target drugs and the circumstances suggesting the likelihood of serotonin toxicity involvement in death. There were 5 cases of reported serotonin toxicity and 23 other deaths suspected to have involved this form of toxicity. Tramadol featured most commonly out of the seven target drugs and was frequently detected in combination with serotonergic antidepressants. MDMA was also detected relatively commonly and was associated with moclobemide in 4 cases of confirmed serotonin toxicity. There were an additional 1095 cases where natural disease, external injury or the misuse of other drugs caused death, of which 2 reported the incidental contribution of serotonin toxicity.
在维多利亚时代的死亡案例中，经常会检测到血清素活性药物。在 2002 年至 2008 年期间，有 1123 例死亡案例，其中一种或多种血清素活性药物曲马多、文拉法辛、氟西汀、舍曲林、西酞普兰、帕罗西汀和 MDMA 被检测到。通过对病理学、毒理学和警方报告进行审查，以确定这些药物对死亡原因的影响，特别是如果是血清素毒性导致了死亡。有 28 例死亡案例引起了我们的关注，因为这些案例中存在目标药物，且存在表明血清素毒性可能与死亡有关的情况。有 5 例报告了血清素毒性，还有 23 例其他死亡案例疑似涉及这种毒性。在这 7 种目标药物中，曲马多最为常见，且经常与血清素能抗抑郁药一起被检测到。MDMA 也相对常见，与莫达非尼一起在 4 例确认的血清素毒性案例中被检测到。还有另外 1095 例死亡案例是由自然疾病、外部伤害或其他药物的滥用导致的，其中 2 例报告了血清素毒性的偶然影响。
