超顺磁性氧化铁纳米粒子 - RGD 肽模拟物偶联物的合成与表征。

Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation.

机构信息

Unité de Chimie Organique et Médicinale, Université Catholique de Louvain, Bâtiment Lavoisier, Louvain-la-Neuve, Belgium.

出版信息

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1861-5. doi: 10.1016/j.bmcl.2010.01.150. Epub 2010 Feb 4.

DOI:10.1016/j.bmcl.2010.01.150

PMID:20172716

Abstract

Ultrasmall particles of iron oxide (USPIOs) coated with 3,3'-bis(phosphonate)propionic acid were covalently coupled to a home-made Arg-Gly-Asp (RGD) peptidomimetic molecule via a short oligoethylene-glycol (OEG) spacer. The conjugation rate was measured by X-ray photoelectron spectroscopy (XPS). The particle size and magnetic characteristics were kept. Our novel conjugate targeted efficiently Jurkat cells (increase of 229% vs the control).

摘要

超顺磁性氧化铁（USPIO）纳米粒子经 3,3'-双（膦酸）丙酸包覆，并通过短链聚乙二醇（OEG）间隔臂与一种自制的精氨酸-甘氨酸-天冬氨酸（RGD）肽模拟物进行共价偶联。偶联率通过 X 射线光电子能谱（XPS）进行测量。纳米粒子的粒径和磁性能保持不变。我们的新型偶联物能有效地靶向 Jurkat 细胞（与对照组相比增加了 229%）。