新型强效水溶性脂质免疫佐剂通过 TLR2 途径诱导小鼠树突状细胞成熟和 B 细胞增殖。
Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway.
机构信息
Equipe de Biovectorologie, Laboratoire de Conception et Application des Molécules Bioactives, UMR 7199 CNRS/Université de Strasbourg, Faculté de Pharmacie, Illkirch Cedex, France.
出版信息
Bioorg Med Chem Lett. 2010 Mar 15;20(6):1869-72. doi: 10.1016/j.bmcl.2010.01.146. Epub 2010 Feb 2.
PMID:20172719
Abstract
Four novel water-soluble lipid immunoadjuvants were designed, synthesized and characterized by MS and NMR. They all induce mouse dendritic cell maturation and B cell proliferation. We demonstrate that in spite of the chemical modification, the four compounds remain TLR2 agonists.
摘要
四种新型水溶性脂质免疫佐剂已通过 MS 和 NMR 进行设计、合成和表征。它们均能诱导小鼠树突状细胞成熟和 B 细胞增殖。我们证明，尽管进行了化学修饰，这四种化合物仍然是 TLR2 激动剂。
Zotero 插件