全国社会生活、健康和老龄化研究中的 C 反应蛋白预测因子。
Predictors of C-reactive protein in the national social life, health, and aging project.
机构信息
Department of Anthropology, Northwestern University, Evanston, IL 60208, USA.
出版信息
J Gerontol B Psychol Sci Soc Sci. 2011 Jan;66(1):129-36. doi: 10.1093/geronb/gbq008. Epub 2010 Feb 19.
Abstract
OBJECTIVE
Inflammation plays an important role in many chronic degenerative diseases associated with aging, and social, economic, and behavioral factors that contribute to inflammation may lead to differential burdens of morbidity and mortality in later life. This study examines socioeconomic status and race/ethnicity as predictors of C-reactive protein (CRP) among older adults in the United States and considers the degree to which health behaviors, medical conditions and medication use, and psychosocial factors account for these associations.
METHODS
Multiple linear regression analysis of survey data for 1,580 participants, 57-85 years of age, in a population-based nationally representative sample of community-residing older adults in the United States.
RESULTS
Educational attainment, household wealth, and race/ethnicity were independently associated with CRP, with limited evidence for interactions with age. Health-related behaviors and usage of medications related to inflammation accounted for substantial proportions of these associations.
DISCUSSION
These results highlight the fundamental causes of inflammation among older adults and suggest pathways through which social disparities in inflammation may be reduced.
摘要
目的
炎症在许多与衰老相关的慢性退行性疾病中起着重要作用，而导致炎症的社会、经济和行为因素可能导致老年人在发病和死亡方面存在差异。本研究在美国老年人中检验了社会经济地位和种族/民族是 C 反应蛋白（CRP）的预测因素，并考虑了健康行为、医疗状况和药物使用以及心理社会因素在多大程度上解释了这些关联。
方法
对美国基于人群的社区居住老年人的全国代表性样本中 1580 名 57-85 岁参与者的调查数据进行多元线性回归分析。
结果
教育程度、家庭财富和种族/民族与 CRP 独立相关，与年龄的相互作用证据有限。与炎症相关的健康相关行为和药物使用解释了这些关联的很大一部分。
讨论
这些结果强调了老年人炎症的根本原因，并提出了可能减少炎症方面社会差异的途径。
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