肿瘤芽生与阳性淋巴结结直肠癌根治性切除术后的生存。

Tumor budding and survival after potentially curative resection of node-positive colon cancer.

机构信息

Department of Anatomical Pathology, Concord Hospital, Sydney, New South Wales, Australia.

出版信息

Dis Colon Rectum. 2010 Mar;53(3):301-7. doi: 10.1007/DCR.0b013e3181c3ed05.

DOI:10.1007/DCR.0b013e3181c3ed05

PMID:20173477

Abstract

PURPOSE

The aim of this study was to investigate the relationship between tumor budding and other pathology features and overall survival after resection of clinicopathological stage III colon cancer.

METHODS

The number of buds and other histopathological features were assessed in 477 patients who were operated on between 1971 and 2001, with follow-up to December 2006. Overall survival was analyzed using the Kaplan-Meier method and Cox regression.

RESULTS

The number of buds was dichotomized as low (0 to 8) vs high (>or=9). High budding was more common in men, in high-grade tumors, in the presence of venous invasion, and where the tumor had involved a free serosal surface, but budding was not associated with 8 other clinical and pathological features. The 5-year survival rate for patients with 0 to 8 buds was 51.0% (95% confidence interval, 44.9-55.1), whereas that for patients with 9 or more buds was 33.9% (95% confidence interval, 25.2-42.8). This association, however, disappeared after adjustment for other variables independently associated with survival (hazard ratio, 1.2; 95% confidence interval, 0.94-1.54; P = .139).

CONCLUSION

In stage III colon cancer, tumor budding did not provide additional independent prognostic information beyond that given by routine pathology reporting.

摘要

目的

本研究旨在探讨肿瘤芽与其他病理特征与临床病理分期 III 期结肠癌切除术后总生存之间的关系。

方法

在 1971 年至 2001 年间进行手术的 477 例患者中评估了芽的数量和其他组织病理学特征，随访至 2006 年 12 月。使用 Kaplan-Meier 方法和 Cox 回归分析总生存情况。

结果

芽的数量被分为低（0 至 8）和高（≥9）。高芽更多见于男性、高级别肿瘤、存在静脉侵犯以及肿瘤累及游离浆膜表面，但芽与其他 8 个临床和病理特征无关。0 至 8 个芽的患者 5 年生存率为 51.0%（95%置信区间，44.9-55.1），而 9 个或更多芽的患者 5 年生存率为 33.9%（95%置信区间，25.2-42.8）。然而，在调整与生存独立相关的其他变量后，这种相关性消失（危险比，1.2；95%置信区间，0.94-1.54；P=0.139）。