Department of Pathology, Laboratory Medicine Programme, University Health Network/University of Toronto, Toronto, Ontario, Canada.
Int J Gynecol Pathol. 2010 Mar;29(2):189-92. doi: 10.1097/PGP.0b013e3181b91a6d.
A 68-year-old woman with stage pT1b1 N0 cervical squamous carcinoma had an incidental cervical polyp. The polyp measured 1.7 cm in maximal diameter and histologic evaluation showed it to be composed of spindle-shaped cells with hypercellular and hypocellular foci. The stroma was collagenized and contained several dilated vascular channels that imparted a hemangiopericytic pattern to the lesion. Immunohistochemistry showed the spindle cells to be positive for vimentin, CD99, CD34, bcl-2, ER, PR, and beta-catenin (cytoplasmic) but negative for EMA, S100, factor XIIIa, AE1/AE3, caldesmon, desmin, CD31, and smooth muscle actin. The morphology and immunophenotype was in keeping with a diagnosis of a solitary fibrous tumor (SFT). SFT shares several histologic features of a superficial cervicovaginal myofibroblastoma; the cellular variability, pattern and distribution of vessels, stromal collagenization, and desmin negativity favors SFT.
一位 68 岁 stage pT1b1 N0 宫颈鳞癌患者，偶然发现宫颈息肉。息肉最大径 1.7cm，组织学评估显示其由梭形细胞组成，伴细胞丰富区和稀疏区。间质胶原化，有几个扩张的血管腔，使病变呈血管外皮细胞瘤样模式。免疫组化显示梭形细胞 vimentin、CD99、CD34、bcl-2、ER、PR 和β-catenin（细胞质）阳性，而 EMA、S100、factor XIIIa、AE1/AE3、钙调蛋白、结蛋白、CD31 和平滑肌肌动蛋白阴性。形态和免疫表型符合孤立性纤维性肿瘤（SFT）的诊断。SFT 与宫颈阴道浅表性肌纤维母细胞瘤有几个组织学特征相似；细胞多样性、血管模式和分布、间质胶原化和结蛋白阴性有利于 SFT 的诊断。
