Zhu Qianlin, Mao Zhihai, Jin Jue, Deng Yunxin, Zheng Minhua, Yu Buwei
Department of Anesthesiology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Surg Laparosc Endosc Percutan Tech. 2010 Feb;20(1):54-7. doi: 10.1097/SLE.0b013e3181ce1462.
The aim of this study was to compare the anesthetic outcomes of elderly and younger patients perioperatively, and to evaluate the safety of this procedure in elderly.
A total of 25 patients undergoing elective laparoscopic colorectal surgery were enrolled in this study prospectively. Ten patients were more than or equal to 70 years (Group E) and 15 patients were less than or equal to 69 years (Group Y). The parameters between groups for perioperative hemodynamics, arterial blood chemistry, and perfusion of intraabdominal organs were recorded and compared periodically from before induction of anesthesia till after the operation.
Group E had a higher ASA degree (P<0.01) than group Y. During the operation, the HCO3 and PaCO2 value increased whereas the pH value decreased significantly. All these parameters recovered gradually at the end of the surgery; some serum electrolytes decreased, especially K and Ca. The central venous pressure increased after volume expansion and the beginning of operation, and then decreased postoperatively. Mean arterial pressure had a marked change during volume expansion period and early after the induction of anesthesia. pHi decreased when the operation began. PgCO2 increased significantly at the end of the surgery. Central venous pressure of group E was higher than that of group Y at 5 minutes during operation, whereas mean arterial pressure of elder group was lower than that of younger group at 15 minutes after the end of operation. Other hemodynamic parameters did not differ significantly from the results.
There is no significantly adverse effect for elderly patients during perioperative period. Adequate intraoperative administration and monitoring are beneficial for maintaining a safe anesthesia.
本研究旨在比较老年患者和年轻患者围手术期的麻醉效果,并评估该手术在老年患者中的安全性。
本研究前瞻性纳入了25例行择期腹腔镜结直肠手术的患者。10例患者年龄大于或等于70岁(E组),15例患者年龄小于或等于69岁(Y组)。从麻醉诱导前至术后,定期记录并比较两组患者围手术期的血流动力学、动脉血液化学指标以及腹腔脏器灌注情况。
E组的ASA分级高于Y组(P<0.01)。手术过程中,HCO3和PaCO2值升高,而pH值显著下降。所有这些参数在手术结束时逐渐恢复;一些血清电解质降低,尤其是钾和钙。扩容和手术开始后中心静脉压升高,术后下降。平均动脉压在扩容期和麻醉诱导后早期有明显变化。手术开始时pHi降低。手术结束时PgCO2显著升高。术中5分钟时E组的中心静脉压高于Y组,而术后15分钟时老年组的平均动脉压低于年轻组。其他血流动力学参数结果无显著差异。
围手术期老年患者无明显不良影响。术中充分给药和监测有利于维持安全麻醉。