Mokady S, Ben-Amotz A
Department of Food Engineering and Biotechnology, Technion, Haifa, Israel.
Nutr Cancer. 1991;15(1):47-52. doi: 10.1080/01635589109514111.
High plasma and tissue levels of beta-carotene have been implicated to be inversely related to the incidence of some types of cancer. Previous studies indicated that the availability of the natural beta-carotene isomer mixture of Dunaliella bardawil was severalfold higher than that of synthetic all-trans beta-carotene. This study illustrated that this higher availability, as expressed by hepatic and plasma beta-carotene, can be further enhanced by increased dietary lipid level. For 12 days, weanling male and female rats were fed diets containing either 0.1% all-trans beta-carotene or spray-dried Dunaliella bardawil having an equal level of the beta-carotene isomer mixture. The diets contained 5 or 15% soybean oil. The rise in dietary fat resulted in a marked increase in plasma and liver beta-carotene, with the Dunaliella isomer mixture being more effective. Higher levels were found in female than in male animals. These findings may be relevant when a high dose of beta-carotene is considered as a potential anticancer agent.
血浆和组织中高浓度的β-胡萝卜素被认为与某些类型癌症的发病率呈负相关。先前的研究表明，巴氏杜氏藻天然β-胡萝卜素异构体混合物的利用率比合成全反式β-胡萝卜素高几倍。这项研究表明，以肝脏和血浆β-胡萝卜素表示的这种较高利用率可通过提高饮食中的脂质水平进一步增强。断奶的雄性和雌性大鼠连续12天喂食含有0.1%全反式β-胡萝卜素或具有同等水平β-胡萝卜素异构体混合物的喷雾干燥巴氏杜氏藻的饲料。饲料中含有5%或15%的大豆油。饮食脂肪的增加导致血浆和肝脏β-胡萝卜素显著增加，其中杜氏藻异构体混合物的效果更明显。雌性动物中的含量高于雄性动物。当高剂量的β-胡萝卜素被视为一种潜在的抗癌剂时，这些发现可能具有相关性。
